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Details on Person Import of DENV RNA from exosomes
Class:Id BlackBoxEvent:9947465
_displayName Import of DENV RNA from exosomes
_doRelease TRUE
_timestamp 2025-12-03 15:39:02
authored [InstanceEdit:9947460] Stephan, Ralf, 2025-05-06
compartment [Compartment:70101] cytosol [Compartment:383505] extracellular exosome
created [InstanceEdit:9947460] Stephan, Ralf, 2025-05-06
disease [Disease:3244610] dengue disease
edited [InstanceEdit:9970206] Stephan, Ralf, 2025-10-29
goBiologicalProcess [GO_BiologicalProcess:2132843] macropinocytosis
input [DefinedSet:9947377] DENV RNA [extracellular exosome] [Dengue virus type 2]
internalReviewed [InstanceEdit:9959999] Matthews, Lisa, 2025-07-04
isChimeric FALSE
literatureReference [LiteratureReference:9947348] Dissemination of the Flavivirus Subgenomic Replicon Genome and Viral Proteins by Extracellular Vesicles [LiteratureReference:9947385] Arthropod EVs mediate dengue virus transmission through interaction with a tetraspanin domain containing glycoprotein Tsp29Fb [LiteratureReference:9947464] Dual Role of Extracellular Vesicles as Orchestrators of Emerging and Reemerging Virus Infections
modified [InstanceEdit:9947487] Stephan, Ralf, 2025-05-06 [InstanceEdit:9960001] Stephan, Ralf, 2025-07-04 [InstanceEdit:9960002] Stephan, Ralf, 2025-07-04 [InstanceEdit:9963605] Stephan, Ralf, 2025-08-15 [InstanceEdit:9964205] Stephan, Ralf, 2025-08-20 [InstanceEdit:9966337] Stephan, Ralf, 2025-09-19 [InstanceEdit:9970205] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970207] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970441] Stephan, Ralf, 2025-10-30 [InstanceEdit:9970472] Stephan, Ralf, 2025-10-30 [InstanceEdit:9975896] Stephan, Ralf, 2025-12-03
name Import of DENV RNA from exosomes
output [DefinedSet:9947376] DENV RNA [cytosol] [Dengue virus type 2]
precedingEvent
previousReviewStatus [ReviewStatus:9821383] three stars
regulatedBy [PositiveRegulation:9947457] Positive regulation by 'HAVCR1 [plasma membrane]' [PositiveRegulation:9947463] Positive regulation by 'CD33 [plasma membrane]' [PositiveRegulation:9947466] Positive regulation by 'TIMD4 [plasma membrane]'
relatedSpecies [Species:3244621] Dengue virus type 2
releaseDate 2025-12-08
reviewed [InstanceEdit:9970204] Mansur, Daniel Santos, 2025-10-29 [InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:9947468] R-HSA-9947465.2
summation [Summation:9947459] DENV genomic RNA can be transferred by extracellular vesicle...
(hasEvent) [Pathway:9918485] Dengue Virus Attachment and Entry [Homo sapiens]
(precedingEvent) [BlackBoxEvent:9947230] Cap-dependent translation of DENV genomic RNA [Homo sapiens] [BlackBoxEvent:9947293] IRES-mediated translation of DENV genomic RNA [Homo sapiens] [Reaction:9947595] HNRNPC binds DENV mRNA [Homo sapiens] [Reaction:9947632] ILF2:ILF3 binds DENV mRNA [Homo sapiens] [Reaction:9947672] YBX1 binds DENV mRNA [Homo sapiens] [Reaction:9947701] ZFP36L1 binds DENV mRNA [Homo sapiens] [Reaction:9947718] DDX6 binds DENV mRNA [Homo sapiens] [Reaction:9948218] HDLBP and RRBP1 bind DENV mRNA [Homo sapiens]
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