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Details on Person Exosomal secretion of DENV RNA and proteins

Class:Id	BlackBoxEvent:9947387
_displayName	Exosomal secretion of DENV RNA and proteins
_doRelease	TRUE
_timestamp	2026-03-03 08:55:33
authored	[InstanceEdit:9947302] Stephan, Ralf, 2025-05-04
compartment	[Compartment:70101] cytosol [Compartment:383505] extracellular exosome
created	[InstanceEdit:9947356] Stephan, Ralf, 2025-05-05
disease	[Disease:3244610] dengue disease
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
goBiologicalProcess	[GO_BiologicalProcess:5083576] exosomal secretion
input	[DefinedSet:9947376] DENV RNA [cytosol] [Dengue virus type 2] [EntityWithAccessionedSequence:5205651] MAP1LC3B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9959990] N-glycan myristoyl-E [plasma membrane] [Dengue virus type 2] [EntityWithAccessionedSequence:9959991] N-glycan prM [plasma membrane] [Dengue virus type 2] [Complex:9919961] NS1 dimer [plasma membrane] [Dengue virus type 2]
internalReviewed	[InstanceEdit:9959999] Matthews, Lisa, 2025-07-04
isChimeric	FALSE
literatureReference	[LiteratureReference:9947348] Dissemination of the Flavivirus Subgenomic Replicon Genome and Viral Proteins by Extracellular Vesicles [LiteratureReference:9947385] Arthropod EVs mediate dengue virus transmission through interaction with a tetraspanin domain containing glycoprotein Tsp29Fb [LiteratureReference:9947464] Dual Role of Extracellular Vesicles as Orchestrators of Emerging and Reemerging Virus Infections [LiteratureReference:9954431] Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization
modified	[InstanceEdit:9947460] Stephan, Ralf, 2025-05-06 [InstanceEdit:9954417] Stephan, Ralf, 2025-06-07 [InstanceEdit:9959987] Stephan, Ralf, 2025-07-04 [InstanceEdit:9960001] Stephan, Ralf, 2025-07-04 [InstanceEdit:9960002] Stephan, Ralf, 2025-07-04 [InstanceEdit:9960009] Stephan, Ralf, 2025-07-04 [InstanceEdit:9963605] Stephan, Ralf, 2025-08-15 [InstanceEdit:9964204] Stephan, Ralf, 2025-08-20 [InstanceEdit:9966301] Stephan, Ralf, 2025-09-14 [InstanceEdit:9966334] Stephan, Ralf, 2025-09-18 [InstanceEdit:9966337] Stephan, Ralf, 2025-09-19 [InstanceEdit:9970207] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970441] Stephan, Ralf, 2025-10-30 [InstanceEdit:9970472] Stephan, Ralf, 2025-10-30 [InstanceEdit:9975896] Stephan, Ralf, 2025-12-03 [InstanceEdit:9980386] Stephan, Ralf, 2026-01-28 [InstanceEdit:9984050] Stephan, Ralf, 2026-03-03
name	Exosomal secretion of DENV RNA and proteins
negativePrecedingEvent	[NegativePrecedingEvent:9960011] Negative relationship: NS5 synthesizes minus strand genome
output	[DefinedSet:9947377] DENV RNA [extracellular exosome] [Dengue virus type 2] [EntityWithAccessionedSequence:9959986] MAP1LC3B [extracellular exosome] [Homo sapiens] [EntityWithAccessionedSequence:9959988] N-glycan myristoyl-E [extracellular exosome] [Dengue virus type 2] [EntityWithAccessionedSequence:9959989] N-glycan prM [extracellular exosome] [Dengue virus type 2] [Complex:9980387] NS1 dimer [extracellular exosome] [Dengue virus type 2]
precedingEvent	[Reaction:9923094] DENV capped genome (+)-RNA dissociates from RC [Homo sapiens] [Reaction:9923097] NS5 acts as a cap 2'-O-methyltransferase to methylate 5’ m7GpppA of DENV genomic +ssRNA [Homo sapiens] [BlackBoxEvent:9946784] DENV mRNA is decapped [Homo sapiens] [Reaction:9923094] DENV capped genome (+)-RNA dissociates from RC [Homo sapiens] [BlackBoxEvent:9946917] XRN1 incompletely hydrolyzes DENV decapped mRNA [Homo sapiens] [BlackBoxEvent:9946784] DENV mRNA is decapped [Homo sapiens] [BlackBoxEvent:9922491] Dengue virion releases its genome [Homo sapiens] [BlackBoxEvent:9922480] Dengue virion gets internalized [Homo sapiens] [BlackBoxEvent:9947662] PS moves from ER to lysosome [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29 [InstanceEdit:9984049] Roque Ascenção, Fernando, 2026-03-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9947393] R-HSA-9947387.2
structureModified	[InstanceEdit:9959987] Stephan, Ralf, 2025-07-04 [InstanceEdit:9980386] Stephan, Ralf, 2026-01-28
summation	[Summation:9947462] DENV genomic RNA (from DENV-2 and DENV-3 strains) and subgen...
(hasEvent)	[Pathway:9918487] Dengue Virus Genome Translation and Replication [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9947465] Import of DENV RNA from exosomes [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984691] Update Tracker - [BlackBoxEvent:9947387] Exosomal secretion of DENV RNA and proteins - v96:[add_removeOutput]
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No pathways have been reviewed or authored by Exosomal secretion of DENV RNA and proteins (9947387)