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Details on Person Error-prone DNA polymerase (REV1, POLH, POLI, POLZ) synthesizes DNA across the short single-stranded lesion

Class:Id	BlackBoxEvent:9947306
_displayName	Error-prone DNA polymerase (REV1, POLH, POLI, POLZ) synthesizes DNA across the short single-stranded lesion
_doRelease	TRUE
_timestamp	2026-04-27 18:36:00
authored	[InstanceEdit:9947317] May, Bruce, 2025-05-03
catalystActivity	[CatalystActivity:9947307] DNA-directed DNA polymerase activity of APEX2:POLH,I,Z,REV1:MonoUb-K164-PCNA:single-strand gap-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9947315] May, Bruce, 2025-05-04
edited	[InstanceEdit:9947317] May, Bruce, 2025-05-03
input	[Complex:9943354] APEX2:POLH,I,Z,REV1:MonoUb-K164-PCNA:single-strand gap-dsDNA [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9980588] Matthews, Lisa, 2026-01-30
isChimeric	FALSE
literatureReference	[LiteratureReference:9968271] DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes [LiteratureReference:9968266] Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η [LiteratureReference:9968272] Error rate and specificity of human and murine DNA polymerase eta [LiteratureReference:9968257] Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota [LiteratureReference:5653634] Human Pol ? purified with accessory subunits is active in translesion DNA synthesis and complements Pol ? in cisplatin bypass [LiteratureReference:9968261] The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation [LiteratureReference:111303] The human REV1 gene codes for a DNA template-dependent dCMP transferase.
modified	[InstanceEdit:9968291] May, Bruce, 2025-10-12 [InstanceEdit:9968328] May, Bruce, 2025-10-13 [InstanceEdit:9973733] May, Bruce, 2025-11-16 [InstanceEdit:9983648] May, Bruce, 2026-02-25 [InstanceEdit:9983927] May, Bruce, 2026-02-28 [InstanceEdit:9987736] May, Bruce, 2026-04-27
name	Error-prone DNA polymerase (REV1, POLH, POLI, POLZ) synthesizes DNA across the short single-stranded lesion
output	[Complex:9947310] APEX2:POLH,I,Z,REV1:MonoUb-K164-PCNA:dsDNA containing nick [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9943350] APEX2 excises 10-12 nucleotides of single-stranded DNA from nicked double-stranded DNA [Homo sapiens] [Reaction:9943320] APEX2 endonucleolytically cleaves deoxyribose phosphate residue (dRP, abasic site, apurinic/apyrimidinic site, AP site) [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-06-17
reviewed	[InstanceEdit:9987727] Yu, Chuanjiang, 2026-04-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9947324] R-HSA-9947306.1
summation	[Summation:9947313] Error-prone DNA polymerases, notably POLH (DNA polymerase et...
(hasEvent)	[Pathway:9968297] Somatic hypermutation of immunoglobulin genes by error-prone base excision repair (BER) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9968753] Ligation of DNA containing a nick after error-prone base excision repair [Homo sapiens]
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