Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person IRES-mediated translation of DENV genomic RNA

Class:Id	BlackBoxEvent:9947293
_displayName	IRES-mediated translation of DENV genomic RNA
_doRelease	TRUE
_timestamp	2025-10-30 11:42:02
authored	[InstanceEdit:9947258] Stephan, Ralf, 2025-05-03
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9947292] Stephan, Ralf, 2025-05-04
disease	[Disease:3244610] dengue disease
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
goBiologicalProcess	[GO_BiologicalProcess:6668] viral translation
input	[EntityWithAccessionedSequence:9922609] DENV m7G(5')pppAm-capped genomic +ssRNA [cytosol] [Dengue virus type 2]
internalReviewed	[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23 [InstanceEdit:9959999] Matthews, Lisa, 2025-07-04
isChimeric	FALSE
literatureReference	[LiteratureReference:9947236] Dengue and Zika Virus 5' Untranslated Regions Harbor Internal Ribosomal Entry Site Functions [LiteratureReference:9947238] The internal ribosome entry site of the Dengue virus mRNA is active when cap-dependent translation initiation is inhibited [LiteratureReference:9947247] Dengue virus utilizes a novel strategy for translation initiation when cap-dependent translation is inhibited [LiteratureReference:9923529] Flavors of Flaviviral RNA Structure: towards an Integrated View of RNA Function from Translation through Encapsidation [LiteratureReference:9966328] PKR-mediated stress response enhances dengue and Zika virus replication
modified	[InstanceEdit:9947302] Stephan, Ralf, 2025-05-04 [InstanceEdit:9947460] Stephan, Ralf, 2025-05-06 [InstanceEdit:9954417] Stephan, Ralf, 2025-06-07 [InstanceEdit:9959795] Stephan, Ralf, 2025-07-02 [InstanceEdit:9960002] Stephan, Ralf, 2025-07-04 [InstanceEdit:9960009] Stephan, Ralf, 2025-07-04 [InstanceEdit:9963605] Stephan, Ralf, 2025-08-15 [InstanceEdit:9964204] Stephan, Ralf, 2025-08-20 [InstanceEdit:9966325] Stephan, Ralf, 2025-09-17 [InstanceEdit:9966334] Stephan, Ralf, 2025-09-18 [InstanceEdit:9966337] Stephan, Ralf, 2025-09-19 [InstanceEdit:9970207] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970441] Stephan, Ralf, 2025-10-30 [InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	IRES-mediated translation of DENV genomic RNA
output	[EntityWithAccessionedSequence:9947246] Nascent polyprotein [cytosol] [Dengue virus type 2]
precedingEvent	[BlackBoxEvent:9922491] Dengue virion releases its genome [Homo sapiens] [BlackBoxEvent:9922480] Dengue virion gets internalized [Homo sapiens] [BlackBoxEvent:9947662] PS moves from ER to lysosome [Homo sapiens] [BlackBoxEvent:9922955] NS5 synthesizes minus strand genome [Homo sapiens] [BlackBoxEvent:9922965] Circularization of (+)-genomic RNA [Homo sapiens] [BlackBoxEvent:9947465] Import of DENV RNA from exosomes [Homo sapiens] [BlackBoxEvent:9947387] Exosomal secretion of DENV RNA and proteins [Homo sapiens] [Reaction:9923094] DENV capped genome (+)-RNA dissociates from RC [Homo sapiens] [Reaction:9923097] NS5 acts as a cap 2'-O-methyltransferase to methylate 5’ m7GpppA of DENV genomic +ssRNA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9947299] R-HSA-9947293.1
structureModified	[InstanceEdit:9959795] Stephan, Ralf, 2025-07-02
summation	[Summation:9947288] Host ribosomes translate DENV genomic RNA, producing a polyp...
(hasEvent)	[Pathway:9918487] Dengue Virus Genome Translation and Replication [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9923067] Nascent polyprotein starts folding in ER [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by IRES-mediated translation of DENV genomic RNA (9947293)