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Details on Person Cap-dependent translation of DENV genomic RNA

Class:Id	BlackBoxEvent:9947230
_displayName	Cap-dependent translation of DENV genomic RNA
_doRelease	TRUE
_timestamp	2025-11-07 08:42:19
authored	[InstanceEdit:9918832] Stephan, Ralf, 2024-08-18
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9947227] Stephan, Ralf, 2025-05-03
disease	[Disease:3244610] dengue disease
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
goBiologicalProcess	[GO_BiologicalProcess:6668] viral translation
input	[EntityWithAccessionedSequence:9922609] DENV m7G(5')pppAm-capped genomic +ssRNA [cytosol] [Dengue virus type 2]
internalReviewed	[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimeric	FALSE
literatureReference	[LiteratureReference:9923529] Flavors of Flaviviral RNA Structure: towards an Integrated View of RNA Function from Translation through Encapsidation [LiteratureReference:9947239] Protein Synthesis Initiation in Eukaryotic Cells [LiteratureReference:9947231] The Organizing Principles of Eukaryotic Ribosome Recruitment [LiteratureReference:9947247] Dengue virus utilizes a novel strategy for translation initiation when cap-dependent translation is inhibited [LiteratureReference:9947236] Dengue and Zika Virus 5' Untranslated Regions Harbor Internal Ribosomal Entry Site Functions [LiteratureReference:9947238] The internal ribosome entry site of the Dengue virus mRNA is active when cap-dependent translation initiation is inhibited [LiteratureReference:9947254] Enhancement of dengue virus translation: role of the 3' untranslated region and the terminal 3' stem-loop domain [LiteratureReference:9922931] Control of dengue virus translation and replication [LiteratureReference:9947255] Biochemistry and Molecular Biology of Flaviviruses [LiteratureReference:9925626] The flavivirus polymerase NS5 regulates translation of viral genomic RNA [LiteratureReference:9947560] Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication [LiteratureReference:9947589] Hyperglycemia exacerbates dengue virus infection by facilitating poly(A)-binding protein-mediated viral translation [LiteratureReference:9947599] Poly(A)-binding protein binds to the non-polyadenylated 3' untranslated region of dengue virus and modulates translation efficiency [LiteratureReference:9947597] NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus replication [LiteratureReference:9947670] Y box-binding protein-1 binds to the dengue virus 3'-untranslated region and mediates antiviral effects [LiteratureReference:9947723] Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3' UTR structures [LiteratureReference:9947724] Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome [LiteratureReference:9946548] Circularization of flavivirus genomic RNA inhibits de novo translation initiation [LiteratureReference:9948245] An RNA-centric dissection of host complexes controlling flavivirus infection [LiteratureReference:9948249] HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins [LiteratureReference:9954464] Identification of Proteins Bound to Dengue Viral RNA In Vivo Reveals New Host Proteins Important for Virus Replication
modified	[InstanceEdit:9947258] Stephan, Ralf, 2025-05-03 [InstanceEdit:9947302] Stephan, Ralf, 2025-05-04 [InstanceEdit:9947460] Stephan, Ralf, 2025-05-06 [InstanceEdit:9947588] Stephan, Ralf, 2025-05-08 [InstanceEdit:9947621] Stephan, Ralf, 2025-05-09 [InstanceEdit:9947676] Stephan, Ralf, 2025-05-10 [InstanceEdit:9947721] Stephan, Ralf, 2025-05-12 [InstanceEdit:9947730] Stephan, Ralf, 2025-05-12 [InstanceEdit:9947761] Stephan, Ralf, 2025-05-13 [InstanceEdit:9948226] Stephan, Ralf, 2025-05-18 [InstanceEdit:9954417] Stephan, Ralf, 2025-06-07 [InstanceEdit:9959795] Stephan, Ralf, 2025-07-02 [InstanceEdit:9959927] Stephan, Ralf, 2025-07-03 [InstanceEdit:9960009] Stephan, Ralf, 2025-07-04 [InstanceEdit:9963605] Stephan, Ralf, 2025-08-15 [InstanceEdit:9964203] Stephan, Ralf, 2025-08-20 [InstanceEdit:9964266] Stephan, Ralf, 2025-08-21 [InstanceEdit:9966325] Stephan, Ralf, 2025-09-17 [InstanceEdit:9966334] Stephan, Ralf, 2025-09-18 [InstanceEdit:9966336] Stephan, Ralf, 2025-09-19 [InstanceEdit:9970207] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970441] Stephan, Ralf, 2025-10-30 [InstanceEdit:9970472] Stephan, Ralf, 2025-10-30 [InstanceEdit:9971555] Stephan, Ralf, 2025-11-07
name	Cap-dependent translation of DENV genomic RNA
output	[EntityWithAccessionedSequence:9947246] Nascent polyprotein [cytosol] [Dengue virus type 2]
precedingEvent	[BlackBoxEvent:9922491] Dengue virion releases its genome [Homo sapiens] [BlackBoxEvent:9922480] Dengue virion gets internalized [Homo sapiens] [BlackBoxEvent:9947662] PS moves from ER to lysosome [Homo sapiens] [BlackBoxEvent:9947465] Import of DENV RNA from exosomes [Homo sapiens] [BlackBoxEvent:9947387] Exosomal secretion of DENV RNA and proteins [Homo sapiens] [Reaction:9923094] DENV capped genome (+)-RNA dissociates from RC [Homo sapiens] [Reaction:9923097] NS5 acts as a cap 2'-O-methyltransferase to methylate 5’ m7GpppA of DENV genomic +ssRNA [Homo sapiens]
regulatedBy	[Requirement:9947228] Requirement by 'EIF4F [cytosol]' [NegativeRegulation:9947303] Negative regulation by 'NS5 [endoplasmic reticulum membrane]' [Requirement:9947586] Requirement by 'PABPC1 [cytosol]' [NegativeRegulation:9947679] Negative regulation by 'YBX1:DENV mRNA [cytosol]' [NegativeRegulation:9947760] Negative regulation by 'DENV circular genomic +ssRNA:RC [endoplasmic reticulum membrane]' [PositiveRegulation:9948221] Positive regulation by 'HDBLP:RRBP1:DENV mRNA [endoplasmic reticulum membrane]'
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9947252] R-HSA-9947230.1
structureModified	[InstanceEdit:9947302] Stephan, Ralf, 2025-05-04 [InstanceEdit:9947588] Stephan, Ralf, 2025-05-08 [InstanceEdit:9947621] Stephan, Ralf, 2025-05-09 [InstanceEdit:9947676] Stephan, Ralf, 2025-05-10 [InstanceEdit:9947721] Stephan, Ralf, 2025-05-12 [InstanceEdit:9947761] Stephan, Ralf, 2025-05-13 [InstanceEdit:9948226] Stephan, Ralf, 2025-05-18 [InstanceEdit:9954417] Stephan, Ralf, 2025-06-07 [InstanceEdit:9959795] Stephan, Ralf, 2025-07-02 [InstanceEdit:9959927] Stephan, Ralf, 2025-07-03
summation	[Summation:9947240] Host ribosomes translate the capped DENV genomic RNA, produc...
(hasEvent)	[Pathway:9918487] Dengue Virus Genome Translation and Replication [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9923067] Nascent polyprotein starts folding in ER [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984645] Update Tracker - [BlackBoxEvent:9947230] Cap-dependent translation of DENV genomic RNA - v96:[add_removeRegulator]
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No pathways have been reviewed or authored by Cap-dependent translation of DENV genomic RNA (9947230)