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Details on Person CYP51A1 14-demethylates 24,25-dhLAN to 4,4-diMeCholesta-8,14-dien-3-ol

Class:Id	Reaction:9947148
_displayName	CYP51A1 14-demethylates 24,25-dhLAN to 4,4-diMeCholesta-8,14-dien-3-ol
_doRelease	TRUE
_timestamp	2025-10-21 22:10:11
authored	[InstanceEdit:9947143] D'Eustachio, Peter, 2025-05-01
catalystActivity	[CatalystActivity:9947144] sterol 14-demethylase activity of CYP51A1 [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9947145] sterol 14-demethylase activity of CYP51A1 [endoplasmic reticulum membrane] Purification of a human cytochrome P-450 isozyme catalyzing lanosterol 14 alpha-demethylation
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:9947147] D'Eustachio, Peter, 2025-05-01
crossReference	[DatabaseIdentifier:9969084] RHEA:45961
edited	[InstanceEdit:9947143] D'Eustachio, Peter, 2025-05-01
input	[SimpleEntity:1130708] 24,25-dhLAN [endoplasmic reticulum membrane] [Complex:8957354] CYP450:Fe2+ [endoplasmic reticulum membrane] [Homo sapiens] [Complex:8957354] CYP450:Fe2+ [endoplasmic reticulum membrane] [Homo sapiens] [Complex:8957354] CYP450:Fe2+ [endoplasmic reticulum membrane] [Homo sapiens] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:29368] O2 [cytosol]
internalReviewed	[InstanceEdit:9947455] D'Eustachio, Peter, 2025-05-05
isChimeric	FALSE
literatureReference	[LiteratureReference:9947138] Sterol 14-demethylase P450 (P45014DM*) is one of the most ancient and conserved P450 species [LiteratureReference:9947152] Purification of a human cytochrome P-450 isozyme catalyzing lanosterol 14 alpha-demethylation [LiteratureReference:194658] The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols
modified	[InstanceEdit:9947155] D'Eustachio, Peter, 2025-05-01 [InstanceEdit:9949603] D'Eustachio, Peter, 2025-05-22 [InstanceEdit:9953268] D'Eustachio, Peter, 2025-05-30 [InstanceEdit:9969083] D'Eustachio, Peter, 2025-10-21
name	CYP51A1 14-demethylates 24,25-dhLAN to 4,4-diMeCholesta-8,14-dien-3-ol 24,25-dihydrolanosterol + 3 reduced (NADPH--hemoprotein reductase) + 3 O2 => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 3 oxidized (NADPH--hemoprotein reductase) + 4 H2O + 4 H(+)
output	[SimpleEntity:9946142] 4,4-diMe-8,14-cholestadien-3b-ol [endoplasmic reticulum membrane] [SimpleEntity:29460] HCOOH [cytosol] [Complex:8957351] CYP450:Fe3+ [endoplasmic reticulum membrane] [Homo sapiens] [Complex:8957351] CYP450:Fe3+ [endoplasmic reticulum membrane] [Homo sapiens] [Complex:8957351] CYP450:Fe3+ [endoplasmic reticulum membrane] [Homo sapiens] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:9755937] DHCR24 reduces LAN to 24,25-dhLAN [Homo sapiens] [Reaction:191366] Squalene 2,3-epoxide cyclizes, forming lanosterol [Homo sapiens] [Reaction:76494] POR reduces CYP450:Fe3+ to CYP450:Fe2+ [Homo sapiens] [Reaction:9947148] CYP51A1 14-demethylates 24,25-dhLAN to 4,4-diMeCholesta-8,14-dien-3-ol [Homo sapiens] [Reaction:9947203] MSMO1 oxidizes 4,4-diMe-5-cholest-8-en-3-ol to 4a-carboxy-4b-me-5a-cholest-8-en-3b-ol [Homo sapiens] [Reaction:9947207] MSMO1 oxidizes 4a-me-5a-cholest-8-en-3b-ol to 4a-carboxy-5a-cholest-8-ene-3b-ol [Homo sapiens] [Reaction:6807053] SC5D desaturates LTHSOL to 7-dehydroCHOL [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-06-18
reviewed	[InstanceEdit:9953269] Hill, David P, 2025-05-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9947154] R-HSA-9947148.2
summation	[Summation:9947153] CYP51A1 (Lanosterol 14-alpha demethylase), inferred to be lo...
(hasEvent)	[Pathway:6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) [Homo sapiens]
(precedingEvent)	[Reaction:76494] POR reduces CYP450:Fe3+ to CYP450:Fe2+ [Homo sapiens] [Reaction:9946140] TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol [Homo sapiens]
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No pathways have been reviewed or authored by CYP51A1 14-demethylates 24,25-dhLAN to 4,4-diMeCholesta-8,14-dien-3-ol (9947148)