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Details on Person XRN1 incompletely hydrolyzes DENV decapped mRNA

Class:IdBlackBoxEvent:9946917
_displayNameXRN1 incompletely hydrolyzes DENV decapped mRNA
_doReleaseTRUE
_timestamp2025-12-03 15:44:51
authored[InstanceEdit:9946773] Stephan, Ralf, 2025-04-28
catalystActivity[CatalystActivity:429949] 5'-3' RNA exonuclease activity of XRN1 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9946920] Stephan, Ralf, 2025-04-29
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
goBiologicalProcess[GO_BiologicalProcess:18480] mRNA catabolic process
input[EntityWithAccessionedSequence:9946776] DENV decapped mRNA [cytosol] [Dengue virus type 2]
[SimpleEntity:29356] H2O [cytosol]
internalReviewed[InstanceEdit:9959999] Matthews, Lisa, 2025-07-04
isChimericFALSE
literatureReference[LiteratureReference:9946903] RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA
[LiteratureReference:9946905] Subgenomic Flaviviral RNAs of Dengue Viruses
[LiteratureReference:9946904] Subgenomic flaviviral RNAs: What do we know after the first decade of research
[LiteratureReference:9946913] The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production
[LiteratureReference:9946914] Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs
[LiteratureReference:9946910] A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability
modified[InstanceEdit:9960001] Stephan, Ralf, 2025-07-04
[InstanceEdit:9960002] Stephan, Ralf, 2025-07-04
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964208] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966334] Stephan, Ralf, 2025-09-18
[InstanceEdit:9966338] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970207] Stephan, Ralf, 2025-10-29
[InstanceEdit:9970441] Stephan, Ralf, 2025-10-30
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
[InstanceEdit:9975896] Stephan, Ralf, 2025-12-03
nameXRN1 incompletely hydrolyzes DENV decapped mRNA
output[GenomeEncodedEntity:9946922] DENV sfRNA [cytosol] [Dengue virus type 2]
[SimpleEntity:9689912] NMP [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[NegativeRegulation:9946927] Negative regulation by 'DENV sfRNA [cytosol]'
regulationReference[RegulationReference:9946919] Negative regulation by 'DENV sfRNA [cytosol]' A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18
[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9946929] R-HSA-9946917.2
summation[Summation:9946906] Host 5'-3' exoribonuclease 1 (XRN1) catalyzes the hydrolysis...
(hasEvent)[Pathway:9918487] Dengue Virus Genome Translation and Replication [Homo sapiens]
(precedingEvent)[Reaction:9946935] DENV sfRNA binds TRIM25 [Homo sapiens]
[BlackBoxEvent:9947387] Exosomal secretion of DENV RNA and proteins [Homo sapiens]
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No pathways have been reviewed or authored by XRN1 incompletely hydrolyzes DENV decapped mRNA (9946917)
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