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Details on Person PAX5, the transcription coactivators CREBBP, the BAF complex...

Class:IdSummation:9946874
_displayNamePAX5, the transcription coactivators CREBBP, the BAF complex...
_timestamp2026-04-27 17:39:37
created[InstanceEdit:9946889] May, Bruce, 2025-04-29
literatureReference[LiteratureReference:9940551] Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function
[LiteratureReference:9940550] The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells
[LiteratureReference:9940526] The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis
[LiteratureReference:9975345] Pax5: a master regulator of B cell development and leukemogenesis
modified[InstanceEdit:9967293] May, Bruce, 2025-09-27
[InstanceEdit:9975347] May, Bruce, 2025-12-01
[InstanceEdit:9987697] May, Bruce, 2026-04-26
[InstanceEdit:9987723] May, Bruce, 2026-04-27
textPAX5, the transcription coactivators CREBBP, the BAF complex, and the MLL3,4 complex, and the basal transcription complex TFIID activate expression of the BACH2 gene (inferred from mouse homologs in Schebesta et al. 2007, McManus et al. 2011, Revilla-I-Domingo et al. 2012). PAX5 is a key regulator of B cell lineage commitment and expression of PAX5 is maintained throughout most stages of B cell development but is downregulated during terminal differentiation into plasma cells (reviewed in Medvedovic et al. 2011).
(summation)[BlackBoxEvent:9940501] PAX5 positively regulates the expression of BACH2 [Homo sapiens]
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No pathways have been reviewed or authored by PAX5, the transcription coactivators CREBBP, the BAF complex... (9946874)
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