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Details on Person DENV mRNA is decapped

Class:IdBlackBoxEvent:9946784
_displayNameDENV mRNA is decapped
_doReleaseTRUE
_timestamp2025-12-03 15:35:45
authored[InstanceEdit:9946666] Stephan, Ralf, 2025-04-27
catalystActivity[CatalystActivity:9946786] RNA exonuclease activity, producing 5'-phosphomonoesters of Unknown enzyme [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9946773] Stephan, Ralf, 2025-04-28
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
goBiologicalProcess[GO_BiologicalProcess:9666324] mRNA methylguanosine-cap decapping
input[EntityWithAccessionedSequence:9922609] DENV m7G(5')pppAm-capped genomic +ssRNA [cytosol] [Dengue virus type 2]
internalReviewed[InstanceEdit:9959999] Matthews, Lisa, 2025-07-04
isChimericFALSE
literatureReference[LiteratureReference:9946903] RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA
modified[InstanceEdit:9946920] Stephan, Ralf, 2025-04-29
[InstanceEdit:9954417] Stephan, Ralf, 2025-06-07
[InstanceEdit:9960001] Stephan, Ralf, 2025-07-04
[InstanceEdit:9960002] Stephan, Ralf, 2025-07-04
[InstanceEdit:9960009] Stephan, Ralf, 2025-07-04
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964203] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966334] Stephan, Ralf, 2025-09-18
[InstanceEdit:9966336] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970207] Stephan, Ralf, 2025-10-29
[InstanceEdit:9970441] Stephan, Ralf, 2025-10-30
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
[InstanceEdit:9975896] Stephan, Ralf, 2025-12-03
nameDENV mRNA is decapped
negativePrecedingEvent[NegativePrecedingEvent:9960008] Negative relationship: NS5 synthesizes minus strand genome
output[EntityWithAccessionedSequence:9946776] DENV decapped mRNA [cytosol] [Dengue virus type 2]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18
[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9946790] R-HSA-9946784.2
summation[Summation:9946779] Since it has been established that DENV RNA can undergo degr...
(hasEvent)[Pathway:9918487] Dengue Virus Genome Translation and Replication [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9946917] XRN1 incompletely hydrolyzes DENV decapped mRNA [Homo sapiens]
[BlackBoxEvent:9947387] Exosomal secretion of DENV RNA and proteins [Homo sapiens]
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