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Details on Person PE binds to mature Dengue virion

Class:Id	Reaction:9946670
_displayName	PE binds to mature Dengue virion
_doRelease	TRUE
_timestamp	2025-12-03 15:44:26
authored	[InstanceEdit:9946540] Stephan, Ralf, 2025-04-26
compartment	[Compartment:396425] exocytic vesicle
created	[InstanceEdit:9946666] Stephan, Ralf, 2025-04-27
disease	[Disease:3244610] dengue disease
edited	[InstanceEdit:9970206] Stephan, Ralf, 2025-10-29
input	[Complex:9923928] Dengue capsid:nxPS:90xE:M:M:E [exocytic vesicle] [Dengue virus type 2] [SimpleEntity:9946664] PE [exocytic vesicle]
internalReviewed	[InstanceEdit:9959999] Matthews, Lisa, 2025-07-04
isChimeric	FALSE
literatureReference	[LiteratureReference:9946658] Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins
modified	[InstanceEdit:9954417] Stephan, Ralf, 2025-06-07 [InstanceEdit:9959927] Stephan, Ralf, 2025-07-03 [InstanceEdit:9960004] Stephan, Ralf, 2025-07-04 [InstanceEdit:9963605] Stephan, Ralf, 2025-08-15 [InstanceEdit:9964208] Stephan, Ralf, 2025-08-20 [InstanceEdit:9966338] Stephan, Ralf, 2025-09-19 [InstanceEdit:9970205] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970207] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970441] Stephan, Ralf, 2025-10-30 [InstanceEdit:9970472] Stephan, Ralf, 2025-10-30 [InstanceEdit:9975896] Stephan, Ralf, 2025-12-03
name	PE binds to mature Dengue virion
output	[Complex:9946662] Dengue capsid:nxPE:nxPS:90xE:M:M:E [exocytic vesicle] [Dengue virus type 2]
precedingEvent	[Reaction:9919050] Furin cleaves prM:E [Homo sapiens] [BlackBoxEvent:9918988] pre-M is N-glycosylated [Homo sapiens] [BlackBoxEvent:9923837] Immature virion localizes to exocytic vesicle [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewed	[InstanceEdit:9970204] Mansur, Daniel Santos, 2025-10-29 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9946674] R-HSA-9946670.2
summation	[Summation:9946636] Virion maturation exposes a lipid pocket on E proteins. Renn...
(hasEvent)	[Pathway:9918476] Assembly and Release of Dengue Virus Virions [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9923824] Mature virion is released [Homo sapiens]
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No pathways have been reviewed or authored by PE binds to mature Dengue virion (9946670)