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Details on Person T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements
| Class:Id | LiteratureReference:9945893 |
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| _displayName | T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements |
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| _timestamp | 2025-04-20 01:43:23 |
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| author | [Person:9945865] Kanhere, Aditi
[Person:9945879] Hertweck, Arnulf
[Person:9945871] Bhatia, Urvashi
[Person:9945868] Gökmen, M Refik
[Person:9665554] Perucha, Esperanza
[Person:9855834] Jackson, Ian
[Person:9945133] Lord, Graham M
[Person:5219041] Jenner, Richard G |
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| created | [InstanceEdit:9945895] May, Bruce, 2025-04-20 |
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| journal | Nat Commun |
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| pages | 1268 |
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| pubMedIdentifier | 23232398 |
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| title | T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements |
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| volume | 3 |
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| year | 2012 |
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| (literatureReference) | [Reaction:9942698] TBX21 binds the IL12RB2 gene [Homo sapiens]
[Reaction:9942723] TBX21 and RUNX3 bind the IFNG gene [Homo sapiens]
[BlackBoxEvent:9942734] TBX21 positively regulates expression of IL12RB2 [Homo sapiens]
[Reaction:9942930] TBX21 binds the C-X-C chemokine receptor type 3 (CXCR3) gene [Homo sapiens]
[Reaction:9942934] TBX21 binds the C-C chemokine receptor type 5 (CCR5) gene [Homo sapiens]
[Pathway:9976102] Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) [Homo sapiens]
[Reaction:9976129] GATA3, CHD4, EP300, NFATC2 (NFAT1), FOS:JUN (AP-1), KLF13, and MAF bind the IL4 gene [Homo sapiens]
[Reaction:9976381] GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene [Homo sapiens]
[Reaction:9976390] GATA3 binds the IL5 gene [Homo sapiens]
[Reaction:9976406] GATA3, CHD4, and the NuRD complex bind the TBX21 (T-BET) gene [Homo sapiens] |
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