Query author contributions in Reactome
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Details on Person Tbx21 and Runx3 bind a silencer located about 2 kb downstrea...
| Class:Id | Summation:9945891 |
|---|---|
| _displayName | Tbx21 and Runx3 bind a silencer located about 2 kb downstrea... |
| _timestamp | 2025-04-20 02:58:45 |
| created | [InstanceEdit:9945895] May, Bruce, 2025-04-20 |
| literatureReference | [LiteratureReference:9942713] The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses [LiteratureReference:9945867] A continuous T-bet expression is required to silence the interleukin-4-producing potential in T helper type 1 cells |
| modified | [InstanceEdit:9945911] May, Bruce, 2025-04-20 |
| text | Tbx21 and Runx3 bind a silencer located about 2 kb downstream of the Il4 coding region (Djuretic et al. 2007, Naoe et al. 2007, Gökmen et al. 2013), causing repression of Il4 expression (Djuretic et al. 2007, Naoe et al. 2007, Zhuang et al. 2009, Zhu et al. 2012, Gökmen et al. 2013). Il4 is an activator of Th2 differentiation, therefore Tbx21 and Runx3 act to restrict differentiation to the Th1 cell type. |
| (summation) | [Reaction:9945888] Tbx21 and Runx3 bind the Il4 gene [Mus musculus] |
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No pathways have been reviewed or authored by Tbx21 and Runx3 bind a silencer located about 2 kb downstrea... (9945891)
