Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Tbx21 and Runx3 bind the Il4 gene

Class:IdReaction:9945888
_displayNameTbx21 and Runx3 bind the Il4 gene
_doReleaseTRUE
_timestamp2025-08-05 16:04:36
authored[InstanceEdit:9945777] May, Bruce, 2025-04-18
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9945895] May, Bruce, 2025-04-20
edited[InstanceEdit:9945777] May, Bruce, 2025-04-18
input[EntityWithAccessionedSequence:9945873] Il4 gene [nucleoplasm] [Mus musculus]
[EntityWithAccessionedSequence:8949288] Runx3 [nucleoplasm] [Mus musculus]
[EntityWithAccessionedSequence:9942501] Tbx21 [nucleoplasm] [Mus musculus]
internalReviewed[InstanceEdit:9957245] Orlic-Milacic, Marija, 2025-06-17
isChimericFALSE
literatureReference[LiteratureReference:9942668] Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
[LiteratureReference:9945885] Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer
[LiteratureReference:9945905] Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4
modified[InstanceEdit:9945911] May, Bruce, 2025-04-20
[InstanceEdit:9957247] May, Bruce, 2025-06-17
[InstanceEdit:9962422] May, Bruce, 2025-08-04
[InstanceEdit:9962434] May, Bruce, 2025-08-05
nameTbx21 and Runx3 bind the Il4 gene
output[Complex:9945874] Tbx21:Runx3:Il4 gene [nucleoplasm] [Mus musculus]
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2025-09-18
reviewed[InstanceEdit:9962418] Barbutti, Isabella, 2025-08-04
[InstanceEdit:9962433] Lord, Graham M, 2025-08-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:9945900] R-MMU-9945888.1
summation[Summation:9945891] Tbx21 and Runx3 bind a silencer located about 2 kb downstrea...
(inferredFrom)[Reaction:9945877] TBX21 and RUNX3 bind the IL4 gene [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Tbx21 and Runx3 bind the Il4 gene (9945888)
Follow Reactome