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Details on Person NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol

Class:Id	Reaction:9945822
_displayName	NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol
_doRelease	TRUE
_timestamp	2025-05-30 18:51:08
authored	[InstanceEdit:9945781] D'Eustachio, Peter, 2025-04-18
catalystActivity	[CatalystActivity:194724] 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity of NSDHL [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9945785] 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity of NSDHL [endoplasmic reticulum membrane] The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:9945825] D'Eustachio, Peter, 2025-04-18
crossReference	[DatabaseIdentifier:9945821] RHEA:46829
edited	[InstanceEdit:9945781] D'Eustachio, Peter, 2025-04-18
input	[SimpleEntity:9945820] 4a-carboxy-4b-me-5a-cholest-8-en-3b-ol [endoplasmic reticulum membrane] [SimpleEntity:29366] NADP+ [cytosol]
internalReviewed	[InstanceEdit:9947660] D'Eustachio, Peter, 2025-05-09
isChimeric	FALSE
literatureReference	[LiteratureReference:9945805] The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase
modified	[InstanceEdit:9945828] D'Eustachio, Peter, 2025-04-18 [InstanceEdit:9947210] D'Eustachio, Peter, 2025-05-02 [InstanceEdit:9949606] D'Eustachio, Peter, 2025-05-22 [InstanceEdit:9953268] D'Eustachio, Peter, 2025-05-30
name	NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH
output	[SimpleEntity:9945802] 4a-me-5a-cholest-8-en-3-one [endoplasmic reticulum membrane] [SimpleEntity:113528] CO2 [cytosol] [SimpleEntity:29364] NADPH [cytosol]
precedingEvent	[Reaction:9947203] MSMO1 oxidizes 4,4-diMe-5-cholest-8-en-3-ol to 4a-carboxy-4b-me-5a-cholest-8-en-3b-ol [Homo sapiens] [Reaction:9946140] TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol [Homo sapiens] [Reaction:76494] POR reduces CYP450:Fe3+ to CYP450:Fe2+ [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-06-18
reviewed	[InstanceEdit:9953269] Hill, David P, 2025-05-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9945827] R-HSA-9945822.1
summation	[Summation:9945823] NSDHL (Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxy...
(hasEvent)	[Pathway:6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) [Homo sapiens]
(precedingEvent)	[Reaction:9945784] HSD17B7 reduces 4a-methyl-5a-cholest-8-en-3-one to 4a-methyl-5a-cholest-8-en-3b-ol [Homo sapiens]
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No pathways have been reviewed or authored by NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol (9945822)