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Details on Person GRHL1, GRHL2 and GRHL3 are human orthologues of the Drosophi...
| Class:Id | Summation:9945527 |
|---|---|
| _displayName | GRHL1, GRHL2 and GRHL3 are human orthologues of the Drosophi... |
| _timestamp | 2026-05-08 13:31:33 |
| created | [InstanceEdit:9945526] Rothfels, Karen, 2025-04-15 |
| modified | [InstanceEdit:9988570] Rothfels, Karen, 2026-05-08 |
| text | GRHL1, GRHL2 and GRHL3 are human orthologues of the Drosophila transcription factor Grainyhead (GRH) (Wilanowski et al, 2002; Ting et al, 2003; Ming et al, 2018; reviewed in Gasperoni et al, 2022). GRHL proteins play roles in epithelial cell development and are additionally implicated in several cancers (Auden et al, 2006; Mlacki et al, 2015; reviewed in Frisch et al, 2017; Gasperoni et al, 2022). GRHL proteins contain a DNA-binding domain that has been shown to recognize an 5'-AACCGGTT-3' sequence (Ting et al, 2005; Nevil et al, 2017). The proteins form homo- and heterodimers and activate transcription by virtue of an N-terminal activation domain (Uv et al, 1994; Attardi and Tjian 1993; Wilanowski et al, 2002; Ting et al, 2003; Ming et al, 2018). |
| (summation) | [Reaction:9945553] GRHL family transcription factors dimerize [Homo sapiens] |
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No pathways have been reviewed or authored by GRHL1, GRHL2 and GRHL3 are human orthologues of the Drosophi... (9945527)
