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Details on Person NS3 localizes to nucleus

Class:IdBlackBoxEvent:9945325
_displayNameNS3 localizes to nucleus
_doReleaseTRUE
_timestamp2025-12-03 15:42:03
authored[InstanceEdit:9945303] Stephan, Ralf, 2025-04-13
compartment[Compartment:13231] nuclear envelope
created[InstanceEdit:9945310] Stephan, Ralf, 2025-04-14
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
goBiologicalProcess[GO_BiologicalProcess:5083567] protein localization to nucleoplasm
input[EntityWithAccessionedSequence:3244645] K27polyUb-NS3 [endoplasmic reticulum membrane] [Dengue virus type 2]
internalReviewed[InstanceEdit:9959999] Matthews, Lisa, 2025-07-04
isChimericFALSE
literatureReference[LiteratureReference:9945323] An ivermectin - atorvastatin combination impairs nuclear transport inhibiting dengue infection in vitro and in vivo
[LiteratureReference:9945311] Nuclear localization of non-structural protein 3 (NS3) during dengue virus infection
[LiteratureReference:9924254] Ivermectin Accelerates Circulating Nonstructural Protein 1 (NS1) Clearance in Adult Dengue Patients: A Combined Phase 2/3 Randomized Double-blinded Placebo Controlled Trial
[LiteratureReference:9945287] Differential localization of dengue virus protease affects cell homeostasis and triggers to thrombocytopenia
modified[InstanceEdit:9945392] Stephan, Ralf, 2025-04-15
[InstanceEdit:9960002] Stephan, Ralf, 2025-07-04
[InstanceEdit:9960009] Stephan, Ralf, 2025-07-04
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964025] Stephan, Ralf, 2025-08-19
[InstanceEdit:9964207] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966334] Stephan, Ralf, 2025-09-18
[InstanceEdit:9966339] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970207] Stephan, Ralf, 2025-10-29
[InstanceEdit:9970441] Stephan, Ralf, 2025-10-30
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
[InstanceEdit:9975896] Stephan, Ralf, 2025-12-03
nameNS3 localizes to nucleus
output[EntityWithAccessionedSequence:9945307] K27polyUb-NS3 [nucleoplasm] [Dengue virus type 2]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[Requirement:9924239] Requirement by 'IMPα/β1 [cytosol]'
[NegativeRegulation:9924261] Negative regulation by 'Importin alpha:Ivermectin [cytosol]'
regulationReference[RegulationReference:9945322] Requirement by 'IMPα/β1 [cytosol]' An ivermectin - atorvastatin combination impairs nuclear transport inhibiting dengue infection in vitro and in vivo
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18
[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9945334] R-HSA-9945325.2
summation[Summation:9945326] Dengue virus NS3 protein localizes to the nucleus in the ear...
(hasEvent)[Pathway:9918432] Maturation of DENV proteins [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9945309] NS3 localizes to ER membrane [Homo sapiens]
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No pathways have been reviewed or authored by NS3 localizes to nucleus (9945325)
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