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Details on Person D'Eustachio, Peter, 2025-04-10
| Class:Id | InstanceEdit:9945102 |
| _displayName | D'Eustachio, Peter, 2025-04-10 |
| _timestamp | 2025-04-10 22:22:08 |
| author | [Person:140934] D'Eustachio, Peter |
| dateTime | 2025-04-10 22:21:56 |
| (created) | [DatabaseIdentifier:9945080] RHEA:15991 [DatabaseIdentifier:9945081] RHEA:22233 [CatalystActivityReference:9945082] C-4 methylsterol oxidase activity of MSMO1 [endoplasmic reticulum membrane] Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay [DatabaseIdentifier:9945083] RHEA:67969 [DatabaseIdentifier:9945084] RHEA:36381 [DatabaseIdentifier:9945085] RHEA:19362 [DatabaseIdentifier:9945086] RHEA:17066 [LiteratureReference:9945087] Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay [Person:9945088] Kratz, Lisa E [ReferenceMolecule:9945089] prenyl diphosphate(3-) [ChEBI:57623] |
| (modified) | [SimpleEntity:191265] PSQPP [cytosol] [SimpleEntity:191290] DMAPP [peroxisomal matrix] [Reaction:191299] Squalene is oxidized to its epoxide [Homo sapiens] [Reaction:191303] FDPS dimer transfers IPPP to GPP [Homo sapiens] [Reaction:191322] FDPS dimer transfers IPPP to DMAPP [Homo sapiens] [Reaction:191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA [Homo sapiens] [SimpleEntity:191324] DMAPP [cytosol] [Reaction:191352] HMGCR dimer reduces bHMG-CoA to MVA [Homo sapiens] [Reaction:191366] Squalene 2,3-epoxide cyclizes, forming lanosterol [Homo sapiens] [Reaction:191380] Mevalonate is phosphorylated to mevalonate-5-phosphate [Homo sapiens] |
| (structureModified) | [Reaction:191380] Mevalonate is phosphorylated to mevalonate-5-phosphate [Homo sapiens] [Reaction:194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one [Homo sapiens] [Reaction:8952137] Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate [Homo sapiens] |
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No pathways have been reviewed or authored by D'Eustachio, Peter, 2025-04-10 (9945102)