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Details on Person TCF19:NuRD represses G6PC gene expression

Class:Id	BlackBoxEvent:9944724
_displayName	TCF19:NuRD represses G6PC gene expression
_doRelease	TRUE
_timestamp	2025-11-20 21:04:43
authored	[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
compartment	[Compartment:7660] nucleoplasm [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9944726] Rothfels, Karen, 2025-04-07
edited	[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
input	[EntityWithAccessionedSequence:9623253] G6PC gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9945020] Orlic-Milacic, Marija, 2025-04-08
isChimeric	FALSE
literatureReference	[LiteratureReference:9944657] Gluconeogenesis Flux in Metabolic Disease [LiteratureReference:9944665] Regulation of gene expression by glycolytic and gluconeogenic enzymes [LiteratureReference:9944666] TCF19 Promotes Cell Proliferation through Binding to the Histone H3K4me3 Mark [LiteratureReference:9944676] Transcription factor 19 interacts with histone 3 lysine 4 trimethylation and controls gluconeogenesis via the nucleosome-remodeling-deacetylase complex
modified	[InstanceEdit:9945052] Rothfels, Karen, 2025-04-09 [InstanceEdit:9974212] Rothfels, Karen, 2025-11-20
name	TCF19:NuRD represses G6PC gene expression
output	[EntityWithAccessionedSequence:71823] G6PC [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:9944712] NuRD binds TCF19 at G6PC gene [Homo sapiens] [Reaction:9940468] CHD and CDK2AP subunits are recruited to NuRD [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9944725] Negative gene expression regulation by 'TCF19:NuRD:G6PC gene:H3K4 nucleosome [nucleoplasm]'
regulationReference	[RegulationReference:9944723] Negative gene expression regulation by 'TCF19:NuRD:G6PC gene:H3K4 nucleosome [nucleoplasm]' Transcription factor 19 interacts with histone 3 lysine 4 trimethylation and controls gluconeogenesis via the nucleosome-remodeling-deacetylase complex
releaseDate	2026-03-25
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9944727] R-HSA-9944724.1
summation	[Summation:9944686] G6PC encodes the catalytic subunit of glucose-6-phosphatase,...
(hasEvent)	[Pathway:9940951] Interaction of NuRD complexes with transcription factors [Homo sapiens]
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No pathways have been reviewed or authored by TCF19:NuRD represses G6PC gene expression (9944724)