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Details on Person CHD6 negatively regulates influenza transcription

Class:Id	BlackBoxEvent:9944255
_displayName	CHD6 negatively regulates influenza transcription
_doRelease	TRUE
_timestamp	2025-11-20 21:00:53
authored	[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
catalystActivity	[CatalystActivity:192665] RNA-directed RNA polymerase activity of Viral Polymerase [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9944254] Rothfels, Karen, 2025-04-03
disease	[Disease:1660558] influenza
edited	[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
input	[SimpleEntity:9757634] NTP [nucleoplasm] [Complex:193302] vRNA (Genomic):NP Complex [nucleoplasm] [Influenza A virus]
internalReviewed	[InstanceEdit:9945020] Orlic-Milacic, Marija, 2025-04-08
literatureReference	[LiteratureReference:9944207] PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators [LiteratureReference:9944177] CHD6 chromatin remodeler is a negative modulator of influenza virus replication that relocates to inactive chromatin upon infection [LiteratureReference:9944184] CHD6, a cellular repressor of influenza virus replication, is degraded in human alveolar epithelial cells and mice lungs during infection [LiteratureReference:9816638] At the centre: influenza A virus ribonucleoproteins [LiteratureReference:9944219] Revisiting influenza A virus life cycle from a perspective of genome balance
modified	[InstanceEdit:9944280] Rothfels, Karen, 2025-04-05 [InstanceEdit:9944306] Rothfels, Karen, 2025-04-04 [InstanceEdit:9945052] Rothfels, Karen, 2025-04-09 [InstanceEdit:9974210] Rothfels, Karen, 2025-11-20
name	CHD6 negatively regulates influenza transcription
output	[DefinedSet:192988] viral mRNA [nucleoplasm] [Influenza A virus]
precedingEvent	[Reaction:9944250] CHD6 binds influenza polymerase and nucleoprotein [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9944253] Negative gene expression regulation by 'CHD6:influenza A RNP [nucleoplasm]'
regulationReference	[RegulationReference:9944252] Negative gene expression regulation by 'CHD6:influenza A RNP [nucleoplasm]' CHD6 chromatin remodeler is a negative modulator of influenza virus replication that relocates to inactive chromatin upon infection
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2026-03-25
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9944256] R-HSA-9944255.1
summation	[Summation:9944278] CHD6 negatively modulates the transcription of negative stra...
(hasEvent)	[Pathway:9943962] CHD6, CHD7, CHD8, CHD9 subfamily [Homo sapiens]
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No pathways have been reviewed or authored by CHD6 negatively regulates influenza transcription (9944255)