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Details on Person CHD6 binds influenza polymerase and nucleoprotein

Class:Id	Reaction:9944250
_displayName	CHD6 binds influenza polymerase and nucleoprotein
_doRelease	TRUE
_timestamp	2025-11-20 21:00:51
authored	[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9944248] Rothfels, Karen, 2025-04-03
disease	[Disease:1660558] influenza
edited	[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
input	[EntityWithAccessionedSequence:9944065] CHD6 [nucleoplasm] [Homo sapiens] [Complex:192720] Viral Polymerase [nucleoplasm] [Influenza A virus] [EntityWithAccessionedSequence:188832] NP [nucleoplasm] [Influenza A virus]
internalReviewed	[InstanceEdit:9945020] Orlic-Milacic, Marija, 2025-04-08
literatureReference	[LiteratureReference:9944207] PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators [LiteratureReference:9944184] CHD6, a cellular repressor of influenza virus replication, is degraded in human alveolar epithelial cells and mice lungs during infection [LiteratureReference:9944177] CHD6 chromatin remodeler is a negative modulator of influenza virus replication that relocates to inactive chromatin upon infection [LiteratureReference:9944219] Revisiting influenza A virus life cycle from a perspective of genome balance [LiteratureReference:9816638] At the centre: influenza A virus ribonucleoproteins [LiteratureReference:192639] Role of the influenza virus M1 protein in nuclear export of viral ribonucleoproteins [LiteratureReference:9944193] Cytoplasmic and nuclear input virus RNPs in influenza virus-infected cells [LiteratureReference:9944195] Influenza virus RNA is synthesized at fixed sites in the nucleus [LiteratureReference:9944236] The synthesis of influenza virus negative-strand RNA takes place in insoluble complexes present in the nuclear matrix fraction [LiteratureReference:169042] A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription [LiteratureReference:9944226] Spliced and unspliced messenger RNAs synthesized from cloned influenza virus M DNA in an SV40 vector: expression of the influenza virus membrane protein (M1) [LiteratureReference:195588] Interaction of influenza virus proteins with nucleosomes [LiteratureReference:9944181] CHD6 is a DNA-dependent ATPase and localizes at nuclear sites of mRNA synthesis
modified	[InstanceEdit:9944305] Rothfels, Karen, 2025-04-04 [InstanceEdit:9945052] Rothfels, Karen, 2025-04-09 [InstanceEdit:9974210] Rothfels, Karen, 2025-11-20
name	CHD6 binds influenza polymerase and nucleoprotein
output	[Complex:9944245] CHD6:influenza A RNP [nucleoplasm] [Homo sapiens]
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2026-03-25
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9944251] R-HSA-9944250.1
summation	[Summation:9944249] CHD6 interacts with all three components (PB1, PB2 and PA) o...
(hasEvent)	[Pathway:9943962] CHD6, CHD7, CHD8, CHD9 subfamily [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9944255] CHD6 negatively regulates influenza transcription [Homo sapiens]
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