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Details on Person CHD6 interacts with all three components (PB1, PB2 and PA) o...

Class:IdSummation:9944249
_displayNameCHD6 interacts with all three components (PB1, PB2 and PA) o...
_timestamp2025-04-08 17:48:13
created[InstanceEdit:9944248] Rothfels, Karen, 2025-04-03
modified[InstanceEdit:9945016] Rothfels, Karen, 2025-04-08
textCHD6 interacts with all three components (PB1, PB2 and PA) of the influenza viral polymerase as well as with the nucleoprotein NP to negatively regulate viral replication and transcription in the nucleus (Huarte et al, 2001; Alfonso et al, 2011; Alfonso et al, 2013).
Negative strand viral RNA, -ssRNA, packaged into ribonucleoprotein particles with NP is the template for both the viral-polymerase-dependent mRNA synthesis and positive strand complementary RNA (cRNA) synthesis. cRNA is then itself a template for further rounds of synthesis of mRNA and vRNA (reviewed in Du et al, 2023; Eisfeld et al, 2015).
Various lines of evidence support an association between viral replication and transcription machinery and host chromatin (Bui et al, 2000; Bukrinskaya et al, 1979; Jackson et al, 1982; Lopez-Turiso et al, 1990; reviewed in Eisfeld et al, 2015; Du et al, 2023). Transcription of viral mRNA from the negative strand RNA viral template depends on priming by 10-12 base pair oligonucleotides scavenged from newly synthesized host mRNA molecules in a process that also depends on host splicing machinery (Plotch et al, 1982; Lamb et al, 1982). In vitro, NP is known to associate with host histone tails (Garcia-Robles et al, 2005). In separate studies, CHD6 was shown to co-localize with RNA polymerase II at sites of mRNA synthesis (Lutz et al, 2006). In studies from the Nieto lab, CHD6 was shown to negatively regulate influenza virus transcription and replication, but also to be a target of viral-mediated degradation along with RNA polymerase II (Huarte et al, 2001; Alfonso et al, 2011; Alfonso et al, 2013).
(summation)[Reaction:9944250] CHD6 binds influenza polymerase and nucleoprotein [Homo sapiens]
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