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Details on Person NEK11 phosphorylates CDC25A

Class:IdReaction:9943676
_displayNameNEK11 phosphorylates CDC25A
_doReleaseTRUE
_timestamp2025-08-18 11:55:21
authored[InstanceEdit:9943824] Orlic-Milacic, Marija, 2025-03-31
catalystActivity[CatalystActivity:9943709] protein serine/threonine kinase activity of p-S273-NEK11 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9943674] Orlic-Milacic, Marija, 2025-03-31
edited[InstanceEdit:9963937] Orlic-Milacic, Marija, 2025-08-18
input[CandidateSet:9943713] p-S76-CDC25A [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
internalReviewed[InstanceEdit:9944280] Rothfels, Karen, 2025-04-05
isChimericFALSE
literatureReference[LiteratureReference:9943654] NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
modified[InstanceEdit:9943719] Orlic-Milacic, Marija, 2025-03-31
[InstanceEdit:9943722] Orlic-Milacic, Marija, 2025-03-31
[InstanceEdit:9943725] Orlic-Milacic, Marija, 2025-03-31
[InstanceEdit:9943976] Orlic-Milacic, Marija, 2025-04-01
[InstanceEdit:9944347] Orlic-Milacic, Marija, 2025-04-04
[InstanceEdit:9944351] Orlic-Milacic, Marija, 2025-04-04
[InstanceEdit:9962476] Orlic-Milacic, Marija, 2025-08-06
[InstanceEdit:9962934] Orlic-Milacic, Marija, 2025-08-12
[InstanceEdit:9963947] Orlic-Milacic, Marija, 2025-08-18
nameNEK11 phosphorylates CDC25A
output[CandidateSet:9943706] p-S76,S79,S82,S88-CDC25A [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent
releaseDate2025-09-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9943680] R-HSA-9943676.1
structureModified[InstanceEdit:9943719] Orlic-Milacic, Marija, 2025-03-31
summation[Summation:9943720]

NEK11, isolated as one of the genes whose knockdown overr...

(hasEvent)[Pathway:69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A [Homo sapiens]
(precedingEvent)[Reaction:69598] Ubiquitination of phosphorylated CDC25A [Homo sapiens]
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