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Details on Person GSK3B phosphorylates CDC25A

Class:IdReaction:9943675
_displayNameGSK3B phosphorylates CDC25A
_doReleaseTRUE
_timestamp2025-08-21 17:12:59
authored[InstanceEdit:9943824] Orlic-Milacic, Marija, 2025-03-31
catalystActivity[CatalystActivity:2022841] protein serine/threonine kinase activity of GSK3B [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9943674] Orlic-Milacic, Marija, 2025-03-31
edited[InstanceEdit:9963937] Orlic-Milacic, Marija, 2025-08-18
input[EntityWithAccessionedSequence:9943689] p-T80-CDC25A [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
internalReviewed[InstanceEdit:9944280] Rothfels, Karen, 2025-04-05
isChimericFALSE
literatureReference[LiteratureReference:9943677] GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers
modified[InstanceEdit:9943700] Orlic-Milacic, Marija, 2025-03-31
[InstanceEdit:9943703] Orlic-Milacic, Marija, 2025-03-31
[InstanceEdit:9943976] Orlic-Milacic, Marija, 2025-04-01
[InstanceEdit:9944347] Orlic-Milacic, Marija, 2025-04-04
[InstanceEdit:9944351] Orlic-Milacic, Marija, 2025-04-04
[InstanceEdit:9962476] Orlic-Milacic, Marija, 2025-08-06
[InstanceEdit:9962934] Orlic-Milacic, Marija, 2025-08-12
[InstanceEdit:9963944] Orlic-Milacic, Marija, 2025-08-18
[InstanceEdit:9964287] Orlic-Milacic, Marija, 2025-08-21
nameGSK3B phosphorylates CDC25A
output[SimpleEntity:113582] ADP [nucleoplasm]
[EntityWithAccessionedSequence:9943698] p-S76,T80-CDC25A [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2025-09-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9943681] R-HSA-9943675.1
structureModified[InstanceEdit:9943700] Orlic-Milacic, Marija, 2025-03-31
summation[Summation:9943701]

GSK3B phosphorylates CDC25A on serine residue S76, which ...

(hasEvent)[Pathway:69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A [Homo sapiens]
(precedingEvent)[Reaction:9943676] NEK11 phosphorylates CDC25A [Homo sapiens]
[Reaction:9943736] Casein kinase I phosphorylates CDC25A [Homo sapiens]
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No pathways have been reviewed or authored by GSK3B phosphorylates CDC25A (9943675)