Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person CHEK1 phosphorylates NEK11

Class:IdReaction:9943662
_displayNameCHEK1 phosphorylates NEK11
_doReleaseTRUE
_timestamp2025-08-18 11:53:29
authored[InstanceEdit:9943824] Orlic-Milacic, Marija, 2025-03-31
catalystActivity[CatalystActivity:143490] protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9943667] Orlic-Milacic, Marija, 2025-03-31
edited[InstanceEdit:9963937] Orlic-Milacic, Marija, 2025-08-18
input[EntityWithAccessionedSequence:9943655] NEK11 [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
internalReviewed[InstanceEdit:9944280] Rothfels, Karen, 2025-04-05
isChimericFALSE
literatureReference[LiteratureReference:9943654] NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
modified[InstanceEdit:9943976] Orlic-Milacic, Marija, 2025-04-01
[InstanceEdit:9944347] Orlic-Milacic, Marija, 2025-04-04
[InstanceEdit:9962476] Orlic-Milacic, Marija, 2025-08-06
[InstanceEdit:9962934] Orlic-Milacic, Marija, 2025-08-12
[InstanceEdit:9963942] Orlic-Milacic, Marija, 2025-08-18
nameCHEK1 phosphorylates NEK11
output[EntityWithAccessionedSequence:9943665] p-S273-NEK11 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent
releaseDate2025-09-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9943670] R-HSA-9943662.1
summation[Summation:9943657] NEK11 kinase is activated by DNA damage in an ATR- and CHEK1...
(hasEvent)[Pathway:69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A [Homo sapiens]
(precedingEvent)[Reaction:9943676] NEK11 phosphorylates CDC25A [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by CHEK1 phosphorylates NEK11 (9943662)