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Details on Person CHD2-dependent H3.3 deposition at MYOG gene

Class:IdReaction:9943614
_displayNameCHD2-dependent H3.3 deposition at MYOG gene
_doReleaseTRUE
_timestamp2025-11-20 21:00:46
authored[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
catalystActivity[CatalystActivity:9943609] ATP hydrolysis activity of CHD2:MYOD heterodimer:MYOG gene with H3 nucleosome [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9943611] ATP hydrolysis activity of CHD2:MYOD heterodimer:MYOG gene with H3 nucleosome [nucleoplasm] Chd2 interacts with H3.3 to determine myogenic cell fate
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9943613] Rothfels, Karen, 2025-03-30
edited[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
inferredFrom
input[Complex:9943573] CHD2:MYOD heterodimer:MYOG gene with H3 nucleosome [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:212295] H3F3A [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:212295] H3F3A [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:113518] H2O [nucleoplasm]
internalReviewed[InstanceEdit:9945020] Orlic-Milacic, Marija, 2025-04-08
isChimericFALSE
literatureReference[LiteratureReference:9943396] Chd2 interacts with H3.3 to determine myogenic cell fate
[LiteratureReference:9677086] Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis
[LiteratureReference:9943545] Epigenetic Regulation of Myogenesis: Focus on the Histone Variants
[LiteratureReference:9943533] Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias
[LiteratureReference:9943541] Epigenetic inheritance of cell differentiation status
[LiteratureReference:9670117] Distinct factors control histone variant H3.3 localization at specific genomic regions
[LiteratureReference:9943521] Transcription-coupled recruitment of human CHD1 and CHD2 influences chromatin accessibility and histone H3 and H3.3 occupancy at active chromatin regions
[LiteratureReference:9943481] CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo
[LiteratureReference:9943382] Human CHD2 is a chromatin assembly ATPase regulated by its chromo- and DNA-binding domains
modified[InstanceEdit:9943629] Rothfels, Karen, 2025-03-30
[InstanceEdit:9944099] Rothfels, Karen, 2025-04-02
[InstanceEdit:9944266] Rothfels, Karen, 2025-04-03
[InstanceEdit:9945052] Rothfels, Karen, 2025-04-09
[InstanceEdit:9974210] Rothfels, Karen, 2025-11-20
nameCHD2-dependent H3.3 deposition at MYOG gene
output[Complex:9943599] CHD2:MYOD heterodimer: MYOG gene with H3.3 nucleosome [nucleoplasm] [Homo sapiens]
[DefinedSet:417237] Replicative histone H3 [nucleoplasm] [Homo sapiens]
[DefinedSet:417237] Replicative histone H3 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113550] Pi [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent
releaseDate2026-03-25
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9943618] R-HSA-9943614.1
structureModified[InstanceEdit:9943629] Rothfels, Karen, 2025-03-30
[InstanceEdit:9944099] Rothfels, Karen, 2025-04-02
summation[Summation:9943570] CHD2 and MYOD are required for the expression of MYOG and ot...
(hasEvent)[Pathway:9943411] CHD1 and CHD2 subfamily [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9943620] CHD2:MYOD heterodimer dependent MYOG gene expression [Homo sapiens]
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No pathways have been reviewed or authored by CHD2-dependent H3.3 deposition at MYOG gene (9943614)
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