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Details on Person CHD1:H3K4me3 interacts with post-initiation transcription complexes

Class:IdReaction:9943567
_displayNameCHD1:H3K4me3 interacts with post-initiation transcription complexes
_doReleaseTRUE
_timestamp2025-11-20 21:00:43
authored[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9943566] Rothfels, Karen, 2025-03-30
edited[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
input[Complex:9943561] CHD1:H3K4me3 chromatin [nucleoplasm] [Homo sapiens]
[Complex:112417] FACT complex [nucleoplasm] [Homo sapiens]
[Complex:8866690] PAF1C [nucleoplasm] [Homo sapiens]
[Complex:71980] U2 snRNP [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9945020] Orlic-Milacic, Marija, 2025-04-08
isChimericFALSE
literatureReference[LiteratureReference:9943471] CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin
[LiteratureReference:9012161] Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing
[LiteratureReference:9943505] Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer
[LiteratureReference:9943497] Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes
[LiteratureReference:9943507] The ATP-dependent chromatin remodeler Chd1 is recruited by transcription elongation factors and maintains H3K4me3/H3K36me3 domains at actively transcribed and spliced genes
[LiteratureReference:9937791] The Chromodomain Helicase DNA-Binding Chromatin Remodelers: Family Traits that Protect from and Promote Cancer
[LiteratureReference:9938062] Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease
modified[InstanceEdit:9945016] Rothfels, Karen, 2025-04-08
[InstanceEdit:9945051] Rothfels, Karen, 2025-04-09
[InstanceEdit:9974210] Rothfels, Karen, 2025-11-20
nameCHD1:H3K4me3 interacts with post-initiation transcription complexes
output[Complex:9943563] CHD1:H3K4 nucleosome:FACT complex:U2 snRNP complex:PAF1C complex [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2026-03-25
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9943568] R-HSA-9943567.1
summation[Summation:9943559] CHD1 interacts with complexes associated with promoter escap...
(hasEvent)[Pathway:9943411] CHD1 and CHD2 subfamily [Homo sapiens]
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