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Details on Person The initial phase of TBX21 expression in naive CD4+ T cells ...

Class:IdSummation:9943432
_displayNameThe initial phase of TBX21 expression in naive CD4+ T cells ...
_timestamp2025-08-04 04:03:22
created[InstanceEdit:9943427] May, Bruce, 2025-03-29
literatureReference[LiteratureReference:9942686] STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and TH1 differentiation
[LiteratureReference:9942696] T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells
[LiteratureReference:9942758] T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
[LiteratureReference:9942729] Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12
[LiteratureReference:9962357] Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse
modified[InstanceEdit:9945163] May, Bruce, 2025-04-11
[InstanceEdit:9945978] May, Bruce, 2025-04-21
[InstanceEdit:9958596] May, Bruce, 2025-06-23
[InstanceEdit:9962364] May, Bruce, 2025-08-04
textThe initial phase of TBX21 expression in naive CD4+ T cells cells is activated by STAT1 dimers phosphorylated on serine-727 that result from IFNG signaling (inferred from mouse homologs in Lighvani et al. 2001, Afkarian et al. 2002, Maldonado et al. 2009) and NFATC1 that result from T cell receptor (TCR) signaling (inferred from mouse homologs in Zhong et al. 2025). A second phase of expression occurs after cessation of TCR signaling and is activated by IL12 acting via IL12RB2 and STAT4 (inferred from mouse cells in Schulz et al. 2009).
(summation)[BlackBoxEvent:9942499] STAT proteins and NFATC1 positively regulate expression of TBX21 during differentiation of T helper 1 cells (Th1 cells) [Homo sapiens]
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