Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Stat1 and Nfatc1 bind the Tbx21 (T-bet) gene

Class:IdReaction:9943424
_displayNameStat1 and Nfatc1 bind the Tbx21 (T-bet) gene
_doReleaseTRUE
_timestamp2025-08-05 15:59:22
authored[InstanceEdit:9943448] May, Bruce, 2025-03-28
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9943427] May, Bruce, 2025-03-29
edited[InstanceEdit:9943448] May, Bruce, 2025-03-28
input[EntityWithAccessionedSequence:9942509] Tbx21 gene [nucleoplasm] [Mus musculus]
[Complex:8986461] 2xp-Y-Stat1 [nucleoplasm] [Mus musculus]
[EntityWithAccessionedSequence:9943439] Nfatc1 [nucleoplasm] [Mus musculus]
internalReviewed[InstanceEdit:9957245] Orlic-Milacic, Marija, 2025-06-17
isChimericFALSE
literatureReference[LiteratureReference:9942729] Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12
[LiteratureReference:9942686] STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and TH1 differentiation
[LiteratureReference:9942696] T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells
[LiteratureReference:9942758] T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
modified[InstanceEdit:9945163] May, Bruce, 2025-04-11
[InstanceEdit:9957247] May, Bruce, 2025-06-17
[InstanceEdit:9962422] May, Bruce, 2025-08-04
[InstanceEdit:9962434] May, Bruce, 2025-08-05
nameStat1 and Nfatc1 bind the Tbx21 (T-bet) gene
output[Complex:9943436] p-Stat1:Nfatc1:Tbx21 gene [nucleoplasm] [Mus musculus]
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2025-09-18
reviewed[InstanceEdit:9962418] Barbutti, Isabella, 2025-08-04
[InstanceEdit:9962433] Lord, Graham M, 2025-08-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:9943455] R-MMU-9943424.1
summation[Summation:9943419] Stat1 and Nfatc1 bind the conserved noncoding sequence 12 (C...
(inferredFrom)[Reaction:9942683] p-STAT1 and NFATC1 bind the TBX21 gene [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Stat1 and Nfatc1 bind the Tbx21 (T-bet) gene (9943424)
Follow Reactome