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Details on Person POLH,POLI,POLZ,REV1 [nucleoplasm]

Class:Id	DefinedSet:9943341
_displayName	POLH,POLI,POLZ,REV1 [nucleoplasm]
_timestamp	2025-11-24 03:24:39
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9943318] May, Bruce, 2025-03-27
hasMember	[Complex:9943337] POLZ tetramer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:110287] POLH [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5656133] POLI [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3006726] REV1 [nucleoplasm] [Homo sapiens]
modified	[InstanceEdit:9974614] May, Bruce, 2025-11-24
name	POLH,POLI,POLZ,REV1 Error-prone DNA polymerase
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9943372] R-HSA-9943341.1
(activeUnit)	[CatalystActivity:9947307] DNA-directed DNA polymerase activity of APEX2:POLH,I,Z,REV1:MonoUb-K164-PCNA:single-strand gap-dsDNA [nucleoplasm]
(hasComponent)	[Complex:9943315] APEX2:POLH,I,Z,REV1:MonoUb-K164-PCNA:single-strand break(AP->5'dRP)-dRP [nucleoplasm] [Homo sapiens] [Complex:9943354] APEX2:POLH,I,Z,REV1:MonoUb-K164-PCNA:single-strand gap-dsDNA [nucleoplasm] [Homo sapiens] [Complex:9943360] APEX2:POLH,I,Z,REV1:MonoUb-K164-PCNA:AP-dsDNA [nucleoplasm] [Homo sapiens] [Complex:9947310] APEX2:POLH,I,Z,REV1:MonoUb-K164-PCNA:dsDNA containing nick [nucleoplasm] [Homo sapiens] [Complex:9968302] POLH,POLI,POLZ,REV1:Ub-PCNA:EXO1:MLH1:PMS2:MSH2:MSH6:ATP:DNA containing single strand nick [nucleoplasm] [Homo sapiens]
(input)	[BlackBoxEvent:9943316] PCNA, APEX2, and error-prone DNA polymerase (POLH, POLI, POLZ, REV1) bind dsDNA with a deoxyribose phosphate residue (abasic site, apurinic/apyrimidinic site, AP site) [Homo sapiens] [BlackBoxEvent:9968303] Error-prone DNA polymerase (REV1, POLH, POLI, POLZ) synthesizes DNA across single strand gap [Homo sapiens]
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No pathways have been reviewed or authored by POLH,POLI,POLZ,REV1 [nucleoplasm] (9943341)