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Details on Person UNG hydrolyzes 2'-deoxyuridine in DNA yielding an abasic site

Class:Id	Reaction:9943321
_displayName	UNG hydrolyzes 2'-deoxyuridine in DNA yielding an abasic site
_doRelease	TRUE
_timestamp	2026-04-27 18:38:17
authored	[InstanceEdit:9943313] May, Bruce, 2025-03-25
catalystActivity	[CatalystActivity:9817516] uracil DNA N-glycosylase activity of UNG-1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9943318] May, Bruce, 2025-03-27
crossReference	[DatabaseIdentifier:9975349] RHEA:81455
edited	[InstanceEdit:9943313] May, Bruce, 2025-03-25
input	[GenomeEncodedEntity:9943243] 2'-deoxyuridine in single-stranded DNA [nucleoplasm] [Homo sapiens] [SimpleEntity:113518] H2O [nucleoplasm]
internalReviewed	[InstanceEdit:9980588] Matthews, Lisa, 2026-01-30
isChimeric	FALSE
literatureReference	[LiteratureReference:9947217] Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination [LiteratureReference:9947222] B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil [LiteratureReference:5637640] Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms [LiteratureReference:9971688] Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans
modified	[InstanceEdit:9947220] May, Bruce, 2025-05-02 [InstanceEdit:9947226] May, Bruce, 2025-05-02 [InstanceEdit:9947327] May, Bruce, 2025-05-04 [InstanceEdit:9971692] May, Bruce, 2025-11-10 [InstanceEdit:9975350] May, Bruce, 2025-12-01 [InstanceEdit:9983648] May, Bruce, 2026-02-25 [InstanceEdit:9983927] May, Bruce, 2026-02-28 [InstanceEdit:9987736] May, Bruce, 2026-04-27
name	UNG hydrolyzes 2'-deoxyuridine in DNA yielding an abasic site
output	[GenomeEncodedEntity:110187] AP-dsDNA [nucleoplasm] [Homo sapiens] [SimpleEntity:29554] Ura [nucleoplasm]
precedingEvent	[Reaction:9943255] AICDA at immunoglobulin variable region deaminates deoxycytidine yielding deoxyuridine [Homo sapiens] [Reaction:9943048] AICDA binds immunoglobulin gene variable region [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-06-17
reviewed	[InstanceEdit:9987727] Yu, Chuanjiang, 2026-04-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9943377] R-HSA-9943321.1
structureModified	[InstanceEdit:9975350] May, Bruce, 2025-12-01
summation	[Summation:9943327] UNG2, the nuclear isoform of UNG, can hydrolyze 2'-deoxyurid...
(hasEvent)	[Pathway:9968297] Somatic hypermutation of immunoglobulin genes by error-prone base excision repair (BER) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9943316] PCNA, APEX2, and error-prone DNA polymerase (POLH, POLI, POLZ, REV1) bind dsDNA with a deoxyribose phosphate residue (abasic site, apurinic/apyrimidinic site, AP site) [Homo sapiens]
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