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Details on Person PCNA, APEX2, and error-prone DNA polymerase (POLH, POLI, POLZ, REV1) bind dsDNA with a deoxyribose phosphate residue (abasic site, apurinic/apyrimidinic site, AP site)

Class:Id	BlackBoxEvent:9943316
_displayName	PCNA, APEX2, and error-prone DNA polymerase (POLH, POLI, POLZ, REV1) bind dsDNA with a deoxyribose phosphate residue (abasic site, apurinic/apyrimidinic site, AP site)
_doRelease	TRUE
_timestamp	2026-04-27 18:37:24
authored	[InstanceEdit:9943313] May, Bruce, 2025-03-25
catalystActivity	[CatalystActivity:9943335] DNA clamp loader activity of RFC Heteropentamer [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9943318] May, Bruce, 2025-03-27
edited	[InstanceEdit:9943313] May, Bruce, 2025-03-25
inferredFrom	[BlackBoxEvent:9967633] Pcna, Apex2, and error-prone DNA polymerase (Polh, Poli, Polz, Rev1) bind dsDNA with a deoxyribose phosphate residue (abasic site, apurinic/apyrimidinic site, AP site) [Mus musculus]
input	[Complex:68440] PCNA homotrimer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9943358] APEX2 [nucleoplasm] [Homo sapiens] [DefinedSet:9943341] POLH,POLI,POLZ,REV1 [nucleoplasm] [Homo sapiens] [GenomeEncodedEntity:110187] AP-dsDNA [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9980588] Matthews, Lisa, 2026-01-30
isChimeric	FALSE
literatureReference	[LiteratureReference:9967655] Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen [LiteratureReference:9967645] Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage [LiteratureReference:9967619] Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA [LiteratureReference:5656095] A single domain in human DNA polymerase iota mediates interaction with PCNA: implications for translesion DNA synthesis [LiteratureReference:9967611] Proliferating cell nuclear antigen-dependent coordination of the biological functions of human DNA polymerase iota [LiteratureReference:9967669] Structural basis of ubiquitin recognition by translesion synthesis DNA polymerase ι [LiteratureReference:9967648] Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin
modified	[InstanceEdit:9967691] May, Bruce, 2025-10-05 [InstanceEdit:9983648] May, Bruce, 2026-02-25 [InstanceEdit:9983927] May, Bruce, 2026-02-28 [InstanceEdit:9987736] May, Bruce, 2026-04-27
name	PCNA, APEX2, and error-prone DNA polymerase (POLH, POLI, POLZ, REV1) bind dsDNA with a deoxyribose phosphate residue (abasic site, apurinic/apyrimidinic site, AP site)
output	[Complex:9943360] APEX2:POLH,I,Z,REV1:MonoUb-K164-PCNA:AP-dsDNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9943321] UNG hydrolyzes 2'-deoxyuridine in DNA yielding an abasic site [Homo sapiens] [Reaction:9943255] AICDA at immunoglobulin variable region deaminates deoxycytidine yielding deoxyuridine [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-06-17
reviewed	[InstanceEdit:9987727] Yu, Chuanjiang, 2026-04-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9943364] R-HSA-9943316.1
summation	[Summation:9943325] Repair of deoxyuridine in DNA is unusually error-prone in pr...
(hasEvent)	[Pathway:9968297] Somatic hypermutation of immunoglobulin genes by error-prone base excision repair (BER) [Homo sapiens]
(precedingEvent)	[Reaction:9943320] APEX2 endonucleolytically cleaves deoxyribose phosphate residue (dRP, abasic site, apurinic/apyrimidinic site, AP site) [Homo sapiens]
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No pathways have been reviewed or authored by PCNA, APEX2, and error-prone DNA polymerase (POLH, POLI, POLZ, REV1) bind dsDNA with a deoxyribose phosphate residue (abasic site, apurinic/apyrimidinic site, AP site) (9943316)