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Details on Person TBX21 directly upregulates expression of the chemokine recep...

Class:IdSummation:9942933
_displayNameTBX21 directly upregulates expression of the chemokine recep...
_timestamp2025-08-04 04:00:42
created[InstanceEdit:9942913] May, Bruce, 2025-03-19
literatureReference[LiteratureReference:9942713] The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses
[LiteratureReference:9943829] Interplay of Chemokines Receptors, Toll-like Receptors, and Host Immunological Pathways
[LiteratureReference:9943845] CXCR3-Expressing T Cells in Infections and Autoimmunity
[LiteratureReference:9942759] A novel transcription factor, T-bet, directs Th1 lineage commitment
[LiteratureReference:9943843] Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes
[LiteratureReference:9943844] CXCR3 in T cell function
[LiteratureReference:9945162] T-bet is required for optimal proinflammatory CD4+ T-cell trafficking
[LiteratureReference:9945155] Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
[LiteratureReference:9946030] TH1/TH2 cell differentiation and molecular signals
modified[InstanceEdit:9943820] May, Bruce, 2025-03-31
[InstanceEdit:9943849] May, Bruce, 2025-04-01
[InstanceEdit:9945163] May, Bruce, 2025-04-11
[InstanceEdit:9946035] May, Bruce, 2025-04-21
[InstanceEdit:9962364] May, Bruce, 2025-08-04
textTBX21 directly upregulates expression of the chemokine receptor CXCR3 in T helper 1 cells (Th1 cells) (inferred from mouse homologs in Szabo et al. 2000, Lord et al. 2005, Zhu et al. 2012). T-bet binds to the 5′ enhancer of the Cxcr3, and without T-bet, H3K4me1 modification is reduced around this binding site (Zhu et al. 2012). Human Th1 cells preferentially express CXCR3 and CCR5 chemokine receptors (Bonecchi et al. 1998). CXCR3 binds three chemokines that are induced by type I interferons: CXCL9 (MIG), CXCL10 (IP‑10), and CXCL11 (I‑TAC) (reviewed in Chu et al. 2023, Rubinstein et al. 2024) to induce the migration of Th1 cells into inflammatory sites (reviewed in Groom and Luster 2011, Zhang et al. 2014).
(summation)[BlackBoxEvent:9942931] TBX21 positively regulates expression of C-X-C chemokine receptor type 3 (CXCR3) [Homo sapiens]
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