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Details on Person TBX21 positively regulates expression of C-X-C chemokine receptor type 3 (CXCR3)

Class:Id	BlackBoxEvent:9942931
_displayName	TBX21 positively regulates expression of C-X-C chemokine receptor type 3 (CXCR3)
_doRelease	TRUE
_timestamp	2025-08-05 16:02:45
authored	[InstanceEdit:9942786] May, Bruce, 2025-03-19
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9942913] May, Bruce, 2025-03-19
edited	[InstanceEdit:9942786] May, Bruce, 2025-03-19
inferredFrom	[BlackBoxEvent:9943794] Tbx21 positively regulates expression of the C-X-C chemokine type 3 receptor (Cxcr3). [Mus musculus]
input	[EntityWithAccessionedSequence:9942921] CXCR3 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9957245] Orlic-Milacic, Marija, 2025-06-17
isChimeric	FALSE
modified	[InstanceEdit:9943820] May, Bruce, 2025-03-31 [InstanceEdit:9943849] May, Bruce, 2025-04-01 [InstanceEdit:9957247] May, Bruce, 2025-06-17 [InstanceEdit:9962422] May, Bruce, 2025-08-04 [InstanceEdit:9962434] May, Bruce, 2025-08-05
name	TBX21 positively regulates expression of C-X-C chemokine receptor type 3 (CXCR3)
output	[EntityWithAccessionedSequence:9943832] CXCR3 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9942930] TBX21 binds the C-X-C chemokine receptor type 3 (CXCR3) gene [Homo sapiens] [BlackBoxEvent:9942499] STAT proteins and NFATC1 positively regulate expression of TBX21 during differentiation of T helper 1 cells (Th1 cells) [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9942920] Positive gene expression regulation by 'TBX21:CXCR3 gene [nucleoplasm]'
releaseDate	2025-09-18
reviewed	[InstanceEdit:9962418] Barbutti, Isabella, 2025-08-04 [InstanceEdit:9962433] Lord, Graham M, 2025-08-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9942949] R-HSA-9942931.1
structureModified	[InstanceEdit:9943849] May, Bruce, 2025-04-01
summation	[Summation:9942933] TBX21 directly upregulates expression of the chemokine recep...
(hasEvent)	[Pathway:9942503] Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) [Homo sapiens]
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No pathways have been reviewed or authored by TBX21 positively regulates expression of C-X-C chemokine receptor type 3 (CXCR3) (9942931)