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Details on Person TBX21 binds the CCR5 gene and activates expression (Referenc...

Class:IdSummation:9942916
_displayNameTBX21 binds the CCR5 gene and activates expression (Referenc...
_timestamp2025-08-04 04:00:04
created[InstanceEdit:9942913] May, Bruce, 2025-03-19
literatureReference[LiteratureReference:9942713] The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses
[LiteratureReference:9945274] Th1/Th2 subsets: distinct differences in homing and chemokine receptor expression?
[LiteratureReference:175616] Identification of a major co-receptor for primary isolates of HIV-1
[LiteratureReference:9946030] TH1/TH2 cell differentiation and molecular signals
modified[InstanceEdit:9945285] May, Bruce, 2025-04-12
[InstanceEdit:9945978] May, Bruce, 2025-04-21
[InstanceEdit:9946035] May, Bruce, 2025-04-21
[InstanceEdit:9957243] May, Bruce, 2025-06-17
[InstanceEdit:9962364] May, Bruce, 2025-08-04
textTBX21 binds the CCR5 gene and activates expression (Reference required). CCR5 is a receptor for the chemokines CCL3 (MIP1A, MIP-1alpha), CCL4 (MIP1B, MIP-1beta), and CCL5 (RANTES) that are produced during inflammation in response to IFNG, TNF, and lipopolysaccharide (reviewed in Syrbe et al. 1999). CCR5 is also a coreceptor for the HIV virus (Deng et al. 1996). CCR5 signaling mediates chemotactic T cell migration (reviewed in Zhang et al. 2014).
(summation)[BlackBoxEvent:9942919] TBX21 positively regulates expression of C-C chemokine receptor type 5 (CCR5) [Homo sapiens]
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