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Details on Person TBX21 positively regulates expression of IL12RB2

Class:Id	BlackBoxEvent:9942734
_displayName	TBX21 positively regulates expression of IL12RB2
_doRelease	TRUE
_timestamp	2025-08-05 16:03:04
authored	[InstanceEdit:9942520] May, Bruce, 2025-03-17
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9942682] May, Bruce, 2025-03-19
edited	[InstanceEdit:9942520] May, Bruce, 2025-03-17
inferredFrom	[BlackBoxEvent:9943450] Tbx21 (T-bet) positively regulates expression of Il12rb2 [Mus musculus]
input	[EntityWithAccessionedSequence:8958138] IL12RB2 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9957245] Orlic-Milacic, Marija, 2025-06-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9945893] T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements
modified	[InstanceEdit:9942966] May, Bruce, 2025-03-19 [InstanceEdit:9942969] May, Bruce, 2025-03-19 [InstanceEdit:9943470] May, Bruce, 2025-03-29 [InstanceEdit:9945904] May, Bruce, 2025-04-20 [InstanceEdit:9957247] May, Bruce, 2025-06-17 [InstanceEdit:9962365] May, Bruce, 2025-08-04 [InstanceEdit:9962422] May, Bruce, 2025-08-04 [InstanceEdit:9962434] May, Bruce, 2025-08-05
name	TBX21 positively regulates expression of IL12RB2
output	[EntityWithAccessionedSequence:447249] IL12RB2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9942698] TBX21 binds the IL12RB2 gene [Homo sapiens] [BlackBoxEvent:9942499] STAT proteins and NFATC1 positively regulate expression of TBX21 during differentiation of T helper 1 cells (Th1 cells) [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9942750] Positive gene expression regulation by 'TBX21:IL12RB2 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9942968] Negative gene expression regulation by 'p-S257-NFATC1 [nucleoplasm]'
releaseDate	2025-09-18
reviewed	[InstanceEdit:9962418] Barbutti, Isabella, 2025-08-04 [InstanceEdit:9962433] Lord, Graham M, 2025-08-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9942782] R-HSA-9942734.1
structureModified	[InstanceEdit:9942969] May, Bruce, 2025-03-19 [InstanceEdit:9962365] May, Bruce, 2025-08-04
summation	[Summation:9942739] TBX21 binds the IL12RB2 gene, which encodes a subunit of the...
(hasEvent)	[Pathway:9942503] Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) [Homo sapiens]
(precedingEvent)	[Reaction:8950063] IL12RB2 binds JAK2 [Homo sapiens]
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No pathways have been reviewed or authored by TBX21 positively regulates expression of IL12RB2 (9942734)