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Details on Person Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12

Class:IdLiteratureReference:9942729
_displayNameSequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12
_timestamp2025-03-19 00:33:15
author[Person:9942712] Schulz, Edda G
[Person:9942673] Mariani, Luca
[Person:9925323] Radbruch, Andreas
[Person:9690045] Höfer, Thomas
created[InstanceEdit:9942682] May, Bruce, 2025-03-19
journalImmunity
pages673-83
pubMedIdentifier19409816
titleSequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12
volume30
year2009
(literatureReference)[Pathway:9942503] Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) [Homo sapiens]
[BlackBoxEvent:9942507] Stat proteins and Nfatc1 positively regulate expression of Tbx21 in CD+ naive T cells [Mus musculus]
[Reaction:9943422] Stat4 binds the Tbx21 (T-bet) gene [Mus musculus]
[Reaction:9943424] Stat1 and Nfatc1 bind the Tbx21 (T-bet) gene [Mus musculus]
[BlackBoxEvent:9943450] Tbx21 (T-bet) positively regulates expression of Il12rb2 [Mus musculus]
[RegulationReference:9943430] Positive gene expression regulation by 'Tbx21:Il12rb2 gene [nucleoplasm]' T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
[Summation:9942684] STAT4 binds to the enhancer and intron of the TBX21 gene. ST...
[Summation:9942739] TBX21 binds the IL12RB2 gene, which encodes a subunit of the...
[Summation:9943432] The initial phase of TBX21 expression in naive CD4+ T cells ...
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