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Details on Person TBX21 and RUNX3 bind the IFNG gene

Class:Id	Reaction:9942723
_displayName	TBX21 and RUNX3 bind the IFNG gene
_doRelease	TRUE
_timestamp	2025-08-05 16:00:00
authored	[InstanceEdit:9942520] May, Bruce, 2025-03-17
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9942682] May, Bruce, 2025-03-19
edited	[InstanceEdit:9942520] May, Bruce, 2025-03-17
inferredFrom	[Reaction:9943423] Tbx21 (T-bet) and Runx3 bind the Ifng gene [Mus musculus]
input	[EntityWithAccessionedSequence:9942502] TBX21 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8877362] IFNG gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8865393] RUNX3 [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9957245] Orlic-Milacic, Marija, 2025-06-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9945148] T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects [LiteratureReference:9945142] The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes [LiteratureReference:9945893] T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements [LiteratureReference:9945883] The Th1 cell regulatory circuitry is largely conserved between human and mouse
modified	[InstanceEdit:9942966] May, Bruce, 2025-03-19 [InstanceEdit:9943470] May, Bruce, 2025-03-29 [InstanceEdit:9945163] May, Bruce, 2025-04-11 [InstanceEdit:9945904] May, Bruce, 2025-04-20 [InstanceEdit:9957247] May, Bruce, 2025-06-17 [InstanceEdit:9962365] May, Bruce, 2025-08-04 [InstanceEdit:9962422] May, Bruce, 2025-08-04 [InstanceEdit:9962434] May, Bruce, 2025-08-05
name	TBX21 and RUNX3 bind the IFNG gene
output	[Complex:9942697] TBX21:RUNX3:IFNG gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9942499] STAT proteins and NFATC1 positively regulate expression of TBX21 during differentiation of T helper 1 cells (Th1 cells) [Homo sapiens] [Reaction:9942683] p-STAT1 and NFATC1 bind the TBX21 gene [Homo sapiens] [Reaction:9942511] STAT4 binds the TBX21 (T-bet) gene [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewed	[InstanceEdit:9962418] Barbutti, Isabella, 2025-08-04 [InstanceEdit:9962433] Lord, Graham M, 2025-08-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9942776] R-HSA-9942723.1
structureModified	[InstanceEdit:9962365] May, Bruce, 2025-08-04
summation	[Summation:9942691] TBX21 (Beima et al. 2006, Jenner et al. 2009, Henderson et a...
(hasEvent)	[Pathway:9942503] Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9942709] TBX21 and RUNX3 positively regulate expression of IFNG [Homo sapiens]
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