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Details on Person Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation
| Class:Id | LiteratureReference:9942710 |
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| _displayName | Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation |
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| _timestamp | 2025-03-19 00:32:59 |
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| author | [Person:2460065] Wei, Lai
[Person:6789956] Vahedi, Golnaz
[Person:6789928] Sun, Hong-Wei
[Person:5684211] Watford, Wendy T
[Person:9942770] Takatori, Hiroaki
[Person:6789984] Ramos, Haydeé L
[Person:6789988] Takahashi, Hayato
[Person:9942730] Liang, Jonathan
[Person:8950670] Gutierrez-Cruz, Gustavo
[Person:9942676] Zang, Chongzhi
[Person:9770821] Peng, Weiqun
[Person:2685493] O'Shea, John J
[Person:6789981] Kanno, Yuka |
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| created | [InstanceEdit:9942682] May, Bruce, 2025-03-19 |
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| journal | Immunity |
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| pages | 840-51 |
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| pubMedIdentifier | 20620946 |
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| title | Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation |
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| volume | 32 |
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| year | 2010 |
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| (literatureReference) | [Summation:9942684] STAT4 binds to the enhancer and intron of the TBX21 gene. ST...
[Summation:9976113] IL4 signaling via IL4RA produces phosphorylated STAT6 dimers...
[Summation:9977219] IL4 signaling produces phosphorylated STAT6 dimers and T cel...
[Pathway:9942503] Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) [Homo sapiens]
[BlackBoxEvent:9942507] Stat proteins and Nfatc1 positively regulate expression of Tbx21 in CD+ naive T cells [Mus musculus]
[Reaction:9943422] Stat4 binds the Tbx21 (T-bet) gene [Mus musculus]
[Pathway:9976102] Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) [Homo sapiens]
[Reaction:9977960] Stat6, Nfatc2 (Nfat1), and Nicd1,2 bind the Gata3 gene and cause displacement of repressor complexes (Prc1, Rbpj:NcoR) by activator complexes (Mll1, Rbpj:Nicd1,2) [Mus musculus]
[BlackBoxEvent:9977991] Stat6, Nfatc2, and Nicd1,2 positiively regulate expression of Gata3 [Mus musculus]
[RegulationReference:9977971] Positive gene expression regulation by 'Mll1:Men1:p-Y641-Stat6:p-S245-Nfatc2:Notch1,2 Coactivator:Gata3 gene [nucleoplasm]' STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells |
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