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Details on Person Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

Class:IdLiteratureReference:9942668
_displayNameTranscription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
_timestamp2025-03-19 00:32:23
author[Person:9942745] Djuretic, Ivana M
[Person:3299463] Levanon, Ditsa
[Person:8865450] Negreanu, Varda
[Person:3299451] Groner, Yoram
[Person:2685301] Rao, Anjana
[Person:8878864] Ansel, K Mark
created[InstanceEdit:9942682] May, Bruce, 2025-03-19
journalNat Immunol
pages145-53
pubMedIdentifier17195845
titleTranscription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
volume8
year2007
(literatureReference)[RegulationReference:9943638] Positive gene expression regulation by 'Tbx21:Runx3:Ifng gene [nucleoplasm]' Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
[Pathway:9942503] Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) [Homo sapiens]
[Reaction:9943423] Tbx21 (T-bet) and Runx3 bind the Ifng gene [Mus musculus]
[BlackBoxEvent:9943630] Tbx21 and Runx3 positively regulate the expression of interferon-gamma (Ifng) [Mus musculus]
[Reaction:9945888] Tbx21 and Runx3 bind the Il4 gene [Mus musculus]
[Complex:9943425] Tbx21:Runx3:Ifng gene [nucleoplasm] [Mus musculus]
[Complex:9945874] Tbx21:Runx3:Il4 gene [nucleoplasm] [Mus musculus]
[Summation:9942691] TBX21 (Beima et al. 2006, Jenner et al. 2009, Henderson et a...
[Summation:9942719] TBX21 and RUNX3 activate transcription of IFNG (inferred fro...
[Summation:9945886] TBX21 (Jenner et al. 2009, Kanhere et al. 2012, and inferred...
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