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Details on Person BCL6 is upregulated after antigen engagement of the B cell r...

Class:Id	Summation:9942442
_displayName	BCL6 is upregulated after antigen engagement of the B cell r...
_timestamp	2025-12-01 07:08:01
created	[InstanceEdit:9942432] May, Bruce, 2025-03-17
literatureReference	[LiteratureReference:9942476] Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity [LiteratureReference:9942477] IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses [LiteratureReference:9942413] IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism [LiteratureReference:9942435] JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells [LiteratureReference:9942463] The molecular basis of IL-21-mediated proliferation
modified	[InstanceEdit:9946770] May, Bruce, 2025-04-27 [InstanceEdit:9975344] May, Bruce, 2025-12-01
text	BCL6 is upregulated after antigen engagement of the B cell receptor and is required for entry of activated B cells into germinal center clusters (inferred from mouse homologs in Kitano et al. 2011). IL21 positively regulates BCL6 expression in B cells (inferred from mouse cells in Linterman et al. 2010, Zotos et al. 2010) via the activation (phosphorylation) of STAT3 by IL21:IL21R:JAK1 signaling (inferred from mouse homologs in Arguni et al. 2006, Zeng et al. 2007).
(summation)	[BlackBoxEvent:9942461] STAT3 and FOSB:JUND (AP-1) positively regulate expression of BCL6 in germinal center B cells [Homo sapiens]
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