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Details on Person OLIG2 binds to the promoter of the CDKN1A gene, encoding tum...
| Class:Id | Summation:9942023 |
|---|---|
| _displayName | OLIG2 binds to the promoter of the CDKN1A gene, encoding tum... |
| _timestamp | 2025-03-13 01:02:01 |
| created | [InstanceEdit:9942010] Orlic-Milacic, Marija, 2025-03-13 |
| literatureReference | [LiteratureReference:9942011] A Comprehensive Profile of ChIP-Seq-Based Olig2 Target Genes in Motor Neuron Progenitor Cells Suggests the Possible Involvement of Olig2 in the Pathogenesis of Amyotrophic Lateral Sclerosis [LiteratureReference:9942018] Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma |
| text | OLIG2 binds to the promoter of the CDKN1A gene, encoding tumor suppressor and TP53 target p21, and represses its transcription (Ligon et al. 2007; Satoh et al. 2015). OLIG2-mediated repression of CDKN1A gene transcription may partly contribute to the growth of normal and malignant neural progenitors and to the resistance of TP53-positive human gliomas to radiation and genotoxic drugs (Mehta et al. 2011). |
| (summation) | [Reaction:9942024] OLIG2 binds CDKN1A gene promoter [Homo sapiens] |
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No pathways have been reviewed or authored by OLIG2 binds to the promoter of the CDKN1A gene, encoding tum... (9942023)
