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Details on Person ZMYND8 is a transcriptional regulator that interacts specifi...
| Class:Id | Summation:9941667 |
|---|---|
| _displayName | ZMYND8 is a transcriptional regulator that interacts specifi... |
| _timestamp | 2025-03-10 16:24:08 |
| created | [InstanceEdit:9941666] Rothfels, Karen, 2025-03-10 |
| text | ZMYND8 is a transcriptional regulator that interacts specifically with the GATAD2A paralog of the NuRD complex (Spruijt et al, 2016). The direct interaction is mediated by the MYND protein-protein interaction domain of ZMYND8 and a PPPL(phi) motif that is present in GATAD2A but not in GATAD2B (Spruijt et al, 2016). ZMYND8 additionally interacts with at least three other zinc-finger transcription factors, ZNF532, ZNF592 and ZNF687, which also co-purify at substoichiometric levels with NuRD complexes (Malovannaya et al, 2011; Eberl et al, 2013; Smits et al, 2013; Spruijt et al, 2016; Ghosh et al, 2018). ZMYND8 appears to play a role in recruiting the GATAD2A-containing NuRD complex to sites of DNA double strand breaks (Gong et al, 2015; Spruijt et al, 2016). |
| (summation) | [Reaction:9940948] GATAD2A NuRD binds ZMYND8:ZNF532:ZNF592:ZNF687 [Homo sapiens] |
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No pathways have been reviewed or authored by ZMYND8 is a transcriptional regulator that interacts specifi... (9941667)
