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Details on Person The antigen bound by the BCR is internalized (inferred from ...
| Class:Id | Summation:9941557 |
|---|---|
| _displayName | The antigen bound by the BCR is internalized (inferred from ... |
| _timestamp | 2026-04-27 17:39:42 |
| created | [InstanceEdit:9941562] May, Bruce, 2025-03-08 |
| literatureReference | [LiteratureReference:9941559] The ins and outs of MHC class II-mediated antigen processing and presentation [LiteratureReference:9946225] B cells acquire antigen from target cells after synapse formation [LiteratureReference:9940583] B cells use mechanical energy to discriminate antigen affinities [LiteratureReference:9946205] B cell ligand discrimination through a spreading and contraction response [LiteratureReference:9966463] B cell receptor (BCR) endocytosis [LiteratureReference:9966460] The Other Function: Class II-Restricted Antigen Presentation by B Cells [LiteratureReference:9979887] B cell antigen receptor signaling and internalization are mutually exclusive events |
| modified | [InstanceEdit:9946352] May, Bruce, 2025-04-23 [InstanceEdit:9946902] May, Bruce, 2025-04-29 [InstanceEdit:9966521] May, Bruce, 2025-09-21 [InstanceEdit:9975344] May, Bruce, 2025-12-01 [InstanceEdit:9979895] May, Bruce, 2026-01-22 [InstanceEdit:9980002] May, Bruce, 2026-01-23 [InstanceEdit:9987697] May, Bruce, 2026-04-26 [InstanceEdit:9987723] May, Bruce, 2026-04-27 |
| text | The antigen bound by the BCR is internalized (inferred from mouse cells in Batista et al. 2001, Fleire et al. 2006, Natkanski et al. 2013, reviewed in Adler et al. 2017, Roberts and Taraska 2023). B cells employ three different mechanisms to endocytose the BCR: phagocytosis, clathrin-mediated endocytosis, and fast endophilin mediated endocytosis (reviewed in Roberts and Taraska 2023). Small pieces of the membrane of the follicular dendritic cell (FDC) are also internalized (inferred from mouse cells in Batista et al. 2001, Natkanski et al. 2013), indicating that the B cell pinches off and excises entire sections of membrane from the FDC rather than only removing the antigen. The antigen is then processed for display on MHC II complexes located on the plasma membrane of the B cell (inferred from mouse cells in Fleire et al. 2006, reviewed in Roche and Furuta 2015). Unphosphorylated BCR is internalized therefore internalization of BCR:antigen and phosphorylation-based signaling by the BCR are dynamically coordinated in space and time (Hou et al. 2006). |
| (summation) | [BlackBoxEvent:9941556] Endocytosis of BCR:Antigen [Homo sapiens] |
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No pathways have been reviewed or authored by The antigen bound by the BCR is internalized (inferred from ... (9941557)
