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Details on Person FKTN transfers RboP to GalNAc-GlcNAc-ManP-DAG1

Class:Id	Reaction:9940735
_displayName	FKTN transfers RboP to GalNAc-GlcNAc-ManP-DAG1
_doRelease	TRUE
_timestamp	2025-06-02 08:57:56
authored	[InstanceEdit:9940797] Stephan, Ralf, 2025-03-02
catalystActivity	[CatalystActivity:9940857] phosphotransferase activity, for other substituted phosphate groups of FKRP:FKTN:RXYLT1 [Golgi membrane]
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:9940703] Stephan, Ralf, 2025-03-06
crossReference	[DatabaseIdentifier:9940803] RHEA:36552
edited	[InstanceEdit:9947109] Stephan, Ralf, 2025-05-01
input	[SimpleEntity:9940856] CDP-ribitol [Golgi lumen] [EntityWithAccessionedSequence:8932424] Core M1,2,3-DAG1 [Golgi lumen] [Homo sapiens]
internalReviewed	[InstanceEdit:9944933] D'Eustachio, Peter, 2025-04-08 [InstanceEdit:9953298] Stephan, Ralf, 2025-06-02
isChimeric	FALSE
literatureReference	[LiteratureReference:9940675] Cell endogenous activities of fukutin and FKRP coexist with the ribitol xylosyltransferase, TMEM5 [LiteratureReference:9940676] Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy [LiteratureReference:9940685] Novel mutations and genotype-phenotype relationships in 107 families with Fukuyama-type congenital muscular dystrophy (FCMD) [LiteratureReference:9940791] A homozygous nonsense mutation in the fukutin gene causes a Walker-Warburg syndrome phenotype [LiteratureReference:9940719] Fukutin gene mutations in steroid-responsive limb girdle muscular dystrophy [LiteratureReference:9940738] Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of α-dystroglycan [LiteratureReference:9940819] Molecular interaction between fukutin and POMGnT1 in the glycosylation pathway of alpha-dystroglycan [LiteratureReference:5617077] Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1 [LiteratureReference:9940822] POMGnT1 mutations in congenital muscular dystrophy: genotype-phenotype correlation and expanded clinical spectrum [LiteratureReference:9940807] Mild POMGnT1 mutations underlie a novel limb-girdle muscular dystrophy variant
modified	[InstanceEdit:9941578] Stephan, Ralf, 2025-03-09 [InstanceEdit:9942597] Stephan, Ralf, 2025-03-18 [InstanceEdit:9944934] Stephan, Ralf, 2025-04-08 [InstanceEdit:9947108] Stephan, Ralf, 2025-05-01 [InstanceEdit:9947328] Stephan, Ralf, 2025-05-05 [InstanceEdit:9948073] Stephan, Ralf, 2025-05-15 [InstanceEdit:9953299] Stephan, Ralf, 2025-06-02 [InstanceEdit:9953301] Stephan, Ralf, 2025-06-02
name	FKTN transfers RboP to GalNAc-GlcNAc-ManP-DAG1
output	[SimpleEntity:727810] CMP [Golgi lumen] [SimpleEntity:425969] H+ [Golgi lumen] [EntityWithAccessionedSequence:9940763] RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen] [Homo sapiens]
precedingEvent	[Reaction:5615637] POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) [Homo sapiens] [Reaction:9913329] Autoproteolysis of DAG1 to alpha and beta chains [Homo sapiens] [Reaction:162715] Reorientation of dolichyl phosphate D-mannose in the endoplasmic reticulum membrane [Homo sapiens] [Reaction:9940804] SLC35A1,4 import CDP-ribitol [Homo sapiens] [Reaction:9940844] CRPPA dimer transfers cytidylyl to Rbt5P [Homo sapiens] [BlackBoxEvent:9940714] Glycosylated alpha-DAG1 localizes to Golgi [Homo sapiens] [Reaction:8931653] POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 [Homo sapiens] [Reaction:8932427] MGAT5B transfers GlcNAc from UDP-GlcNAc to GlcNAc-Man-DAG1 [Homo sapiens] [Reaction:5617037] POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2025-06-18
reviewed	[InstanceEdit:9947107] Zaru, Rossana, 2025-05-01 [InstanceEdit:9948068] Hill, David P, 2025-05-15 [InstanceEdit:9953300] Matthews, Lisa, 2025-06-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9940890] R-HSA-9940735.1
structureModified	[InstanceEdit:9941578] Stephan, Ralf, 2025-03-09 [InstanceEdit:9948073] Stephan, Ralf, 2025-05-15
summation	[Summation:9940688] The ribitol-5-phosphate transferase FKTN subunit of the FKRP...
(hasEvent)	[Pathway:9939291] Matriglycan biosynthesis on DAG1 [Homo sapiens]
(precedingEvent)	[Reaction:9940756] FKRP dimer transfers RboP to matriglycan chain [Homo sapiens]
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No pathways have been reviewed or authored by FKTN transfers RboP to GalNAc-GlcNAc-ManP-DAG1 (9940735)