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Details on Person B cell receptor of germinal B cell binds antigen presented by follicular dendritic cell

Class:IdReaction:9940575
_displayNameB cell receptor of germinal B cell binds antigen presented by follicular dendritic cell
_doReleaseTRUE
_timestamp2026-04-27 18:34:44
authored[InstanceEdit:9940598] May, Bruce, 2025-03-03
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9940597] May, Bruce, 2025-03-06
edited[InstanceEdit:9940598] May, Bruce, 2025-03-03
inferredFrom
input[Complex:9940569] ICAM1 dimer [plasma membrane] [Homo sapiens]
[DefinedSet:9940561] CR1:C3b:IgG:Antigen,CR2:C3d:IgG:Antigen,FCGR2B:IgG:Antigen [plasma membrane] [Homo sapiens]
[Complex:983677] BCR [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:5667169] TNFRSF13C [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:5667169] TNFRSF13C [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:5667169] TNFRSF13C [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:197834] VCAM1 [plasma membrane] [Homo sapiens]
[Complex:198201] ITGA4:ITGB1 [plasma membrane] [Homo sapiens]
[Complex:198196] Integrin alphaLbeta2 [plasma membrane] [Homo sapiens]
[Complex:198196] Integrin alphaLbeta2 [plasma membrane] [Homo sapiens]
[Complex:9987694] TNFSF13B trimer [plasma membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9980588] Matthews, Lisa, 2026-01-30
isChimericFALSE
literatureReference[LiteratureReference:9940516] Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation
[LiteratureReference:198943] Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution.
[LiteratureReference:9946221] Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells
[LiteratureReference:9946282] Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency
modified[InstanceEdit:9941550] May, Bruce, 2025-03-07
[InstanceEdit:9946228] May, Bruce, 2025-04-22
[InstanceEdit:9946283] May, Bruce, 2025-04-23
[InstanceEdit:9966300] May, Bruce, 2025-09-14
[InstanceEdit:9966521] May, Bruce, 2025-09-21
[InstanceEdit:9979724] May, Bruce, 2026-01-21
[InstanceEdit:9983648] May, Bruce, 2026-02-25
[InstanceEdit:9983922] May, Bruce, 2026-02-28
[InstanceEdit:9983927] May, Bruce, 2026-02-28
[InstanceEdit:9987697] May, Bruce, 2026-04-26
[InstanceEdit:9987736] May, Bruce, 2026-04-27
nameB cell receptor of germinal B cell binds antigen presented by follicular dendritic cell
output[Complex:9940565] ITGAL:ITGB2 (GC B cell):ICAM1 dimer (follicular dendritic cell) [plasma membrane] [Homo sapiens]
[Complex:9940559] ITGA4:ITGB1 (GC B cell):VCAM1 (follicular dendritic cell) [plasma membrane] [Homo sapiens]
[Complex:9940593] TNFRSF13C (GC B cell):TNFSF13B trimer (follicular dendritic cell) [plasma membrane] [Homo sapiens]
[Complex:9940588] BCR (GC B cell):Immune complex (follicular dendritic cell) [plasma membrane] [Homo sapiens]
participantCellType[PhysicalEntityCellType:9966286] BCR [plasma membrane] in germinal center B cell
[PhysicalEntityCellType:9966257] TNFRSF13C [plasma membrane] in germinal center B cell
[PhysicalEntityCellType:9966290] VCAM1 [plasma membrane] in follicular dendritic cell
[PhysicalEntityCellType:9966280] CR1:C3b:IgG:Antigen,CR2:C3d:IgG:Antigen,FCGR2B:IgG:Antigen [plasma membrane] in follicular dendritic cell (mouse)
[PhysicalEntityCellType:9966251] ICAM1 dimer [plasma membrane] in follicular dendritic cell
[PhysicalEntityCellType:9966274] ITGA4:ITGB1 [plasma membrane] in germinal center B cell
[PhysicalEntityCellType:9966264] Integrin alphaLbeta2 [plasma membrane] in germinal center B cell
[PhysicalEntityCellType:9966283] TNFSF13B trimer [plasma membrane] in follicular dendritic cell
releaseDate2026-06-17
reviewed[InstanceEdit:9987727] Yu, Chuanjiang, 2026-04-27
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9940612] R-HSA-9940575.1
structureModified[InstanceEdit:9966300] May, Bruce, 2025-09-14
[InstanceEdit:9979724] May, Bruce, 2026-01-21
[InstanceEdit:9983922] May, Bruce, 2026-02-28
[InstanceEdit:9987697] May, Bruce, 2026-04-26
summation[Summation:9941540] Interactions between B cells and follicular dendritic cells ...
(hasEvent)[Pathway:9938027] Affinity selection of immunoglobulins [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9940541] B cell receptor (BCR) extracts antigen from follicular dendritic cell [Homo sapiens]
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No pathways have been reviewed or authored by B cell receptor of germinal B cell binds antigen presented by follicular dendritic cell (9940575)
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