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Details on Person In mammals, the interaction of flagellin with TLR5 induces a...
| Class:Id | Summation:993998 |
|---|---|
| _displayName | In mammals, the interaction of flagellin with TLR5 induces a... |
| _timestamp | 2011-02-21 19:26:47 |
| created | [InstanceEdit:993985] Shamovsky, V, 2010-11-05 |
| literatureReference | [LiteratureReference:993997] Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility [LiteratureReference:1216475] Identification and functional characterization of chicken toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar typhimurium [LiteratureReference:451476] Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin |
| modified | [InstanceEdit:1216499] Shamovsky, V, 2011-02-14 [InstanceEdit:1220566] Shamovsky, V, 2011-02-21 |
| text | In mammals, the interaction of flagellin with TLR5 induces a signaling cascade that utilizes MyD88 adaptor, IRAK family members, and downstream signaling mediators such as MAP kinases and NF-kB that regulate pro-inflammatory genes [Smith KD et al 2003]. The chicken tlr5 gene was cloned from the chicken NCSU macrophage cell line; It encodes a protein of 861 amino acids. The cloned chTLR5 showed 69% and 68% overall amino acid similarity to human and murine TLR5, respectively (Keestra AM et al, 2008). Chicken TLR5 mRNA is expressed in a broad range of tissues, immune cell subsets and chicken cell lines. The strongest signal was detected in colon, spleen, kidney, lung, heart, and testes (Iqbal M et al, 2005). Comparisons of gene structure, genomic location, amino acid composition, and patterns of leucine-rich regions (LRR) consistent with the suggestion that chTLR5 is an orthologue of mammalian TLR5. Like its mammalian counterpart chTLR5 was reported to respond to bacterial flagellin (Iqbal M et al., 2005 and Keestra AM et al.,2008). |
| (summation) | [Pathway:451534] TLR5 cascade [Gallus gallus] |
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