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Details on Person kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin

Class:Id	Reaction:9938539
_displayName	kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin
_doRelease	TRUE
_timestamp	2026-01-27 16:20:36
authored	[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
catalystActivity	[CatalystActivity:9938536] serine-type endopeptidase activity of kallikrein:KNG1:C1QBP, C1QBP:KRT1, PLAUR:KRT1 [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9938542] Shamovsky, Veronica, 2025-02-18
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
input	[Complex:9909045] kallikrein:KNG1:C1QBP, C1QBP:KRT1, PLAUR:KRT1 [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9945130] D'Eustachio, Peter, 2025-04-10
literatureReference	[LiteratureReference:158381] Human high molecular weight kininogen. Studies of structure-function relationships and of proteolysis of the molecule occurring during contact activation of plasma. [LiteratureReference:158183] The amino acid sequence of the light chain of human high-molecular-mass kininogen [LiteratureReference:158413] Completion of the primary structure of human high-molecular-mass kininogen. The amino acid sequence of the entire heavy chain and evidence for its evolution by gene triplication. [LiteratureReference:158182] High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation
modified	[InstanceEdit:9938633] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938677] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938813] Shamovsky, Veronica, 2025-02-19 [InstanceEdit:9938860] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9946125] Shamovsky, Veronica, 2025-04-21 [InstanceEdit:9979569] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980358] Shamovsky, Veronica, 2026-01-27
name	kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin
output	[Complex:158140] Plasma kallikrein [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158344] Bradykinin [extracellular region] [Homo sapiens] [Complex:9938538] cleaved kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) [Homo sapiens] [Reaction:9909048] prekallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor:factor XII (FXII catalyst) [Homo sapiens] [Reaction:9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst) [Homo sapiens] [Reaction:9857952] prekallikrein:kininogen binds cell surface receptors [Homo sapiens] [Reaction:9855735] factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) [Homo sapiens] [Reaction:9857814] prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
reviewed	[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9938543] R-HSA-9938539.1
summation	[Summation:9938537] The proteolytic cleavage of high molecular weight kininogen ...
(hasEvent)	[Pathway:9855689] factor XIIa activates plasma kallikrein-kinin system [Homo sapiens] [Pathway:9970672] FXIIa activates plasma kallikrein-kinin system [Homo sapiens] [Pathway:9970685] Bradykinin metabolism [Homo sapiens]
(precedingEvent)	[Reaction:158340] kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin [Homo sapiens] [Reaction:158399] kallikrein binds SERPING1 [Homo sapiens] [FailedReaction:9651467] SERPING1 variant does not bind kallikrein [Homo sapiens] [Reaction:9655046] Cleavage of FXII variant by KLKB1 [Homo sapiens] [Reaction:9970671] CPM cleaves bradykinin [Homo sapiens] [Reaction:9970703] Bradykinin binds B2 bradykinin receptor [Homo sapiens] [Reaction:9970704] CPN cleaves bradykinin [Homo sapiens]
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No pathways have been reviewed or authored by kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin (9938539)