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Details on Person BCL6 and BACH2:MAFK bind the PRDM1 (BLIMP1) gene

Class:Id	Reaction:9938014
_displayName	BCL6 and BACH2:MAFK bind the PRDM1 (BLIMP1) gene
_doRelease	TRUE
_timestamp	2026-04-27 18:35:02
authored	[InstanceEdit:9938033] May, Bruce, 2025-02-09
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9938038] May, Bruce, 2025-02-10
edited	[InstanceEdit:9938033] May, Bruce, 2025-02-09
inferredFrom	[Reaction:9967244] Bcl6 and Bach2:Mafk bind the Prdm1 (Blimp) gene [Mus musculus]
input	[EntityWithAccessionedSequence:5223066] BCL6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6804192] PRDM1 Gene [nucleoplasm] [Homo sapiens] [Complex:9938035] BACH2:MAFK [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9980588] Matthews, Lisa, 2026-01-30
isChimeric	FALSE
literatureReference	[LiteratureReference:9938040] Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation
modified	[InstanceEdit:9940650] May, Bruce, 2025-03-06 [InstanceEdit:9942488] May, Bruce, 2025-03-17 [InstanceEdit:9967293] May, Bruce, 2025-09-27 [InstanceEdit:9983648] May, Bruce, 2026-02-25 [InstanceEdit:9983927] May, Bruce, 2026-02-28 [InstanceEdit:9987736] May, Bruce, 2026-04-27
name	BCL6 and BACH2:MAFK bind the PRDM1 (BLIMP1) gene
output	[Complex:9938039] BCL6:BACH2:MAFK:PRDM1 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9942461] STAT3 and FOSB:JUND (AP-1) positively regulate expression of BCL6 in germinal center B cells [Homo sapiens] [Reaction:9946750] p-Y-STAT3 dimer and FOSB:JUND (AP-1) bind the BCL6 gene [Homo sapiens] [BlackBoxEvent:9940501] PAX5 positively regulates the expression of BACH2 [Homo sapiens] [Reaction:9940496] PAX5, BAF, TFIID, CREBBP, and MLL3,4 complex bind the BACH2 gene [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-06-17
reviewed	[InstanceEdit:9987727] Yu, Chuanjiang, 2026-04-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9938058] R-HSA-9938014.1
summation	[Summation:9938020] BCL6 and the BACH2:MAFK heterodimer bind the PRDM1 (BLIMP1) ...
(hasEvent)	[Pathway:9938024] Somatic hypermutation of immunoglobulin genes [Homo sapiens]
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No pathways have been reviewed or authored by BCL6 and BACH2:MAFK bind the PRDM1 (BLIMP1) gene (9938014)