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Details on Person AMP-activated protein kinase (AMPK), activated in response t...
| Class:Id | Summation:9937966 |
|---|---|
| _displayName | AMP-activated protein kinase (AMPK), activated in response t... |
| _timestamp | 2025-08-08 21:27:31 |
| created | [InstanceEdit:9937963] Tiwari, Krishna, 2025-02-10 |
| literatureReference | [LiteratureReference:9935388] Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 [LiteratureReference:9935371] Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade |
| modified | [InstanceEdit:9937969] Tiwari, Krishna, 2025-02-10 [InstanceEdit:9938516] Tiwari, Krishna, 2025-02-17 [InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08 |
| text | AMP-activated protein kinase (AMPK), activated in response to metformin, directly binds with PD-L1 (CD274) and phosphorylates S195 of PD-L1. This phosphorylation induces abnormal PD-L1 glycosylation (abnormal mannose trimming), resulting in its endoplasmic reticulum (ER) accumulation and ER-associated protein degradation (ERAD) (Cha et al., 2018, Dai et al., 2021). In addition to Ser195, AMPK phosphorylates Ser283 on PD-L1, which promotes its lysosome-mediated degradation (Dai et al., 2021). |
| (summation) | [Reaction:9931292] AMPK phosphorylates CD274 [Homo sapiens] |
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No pathways have been reviewed or authored by AMP-activated protein kinase (AMPK), activated in response t... (9937966)
