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Details on Person TRMT61B methylates adenosine-616 and adenosine-617 of MT-CYB mRNA

Class:Id	Reaction:9937529
_displayName	TRMT61B methylates adenosine-616 and adenosine-617 of MT-CYB mRNA
_doRelease	TRUE
_timestamp	2025-05-23 14:05:27
authored	[InstanceEdit:9937506] May, Bruce, 2025-01-31
catalystActivity	[CatalystActivity:9937525] mRNA (adenine-N1-)-methyltransferase activity of TRMT61B tetramer [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9937526] May, Bruce, 2025-02-01
edited	[InstanceEdit:9937506] May, Bruce, 2025-01-31
input	[EntityWithAccessionedSequence:6792969] MT-CYB mRNA [mitochondrial matrix] [Homo sapiens] [SimpleEntity:2162265] AdoMet [mitochondrial matrix] [SimpleEntity:2162265] AdoMet [mitochondrial matrix]
internalReviewed	[InstanceEdit:9938470] Matthews, Lisa, 2025-02-16
isChimeric	FALSE
literatureReference	[LiteratureReference:9937527] Base-Resolution Mapping Reveals Distinct m¹A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts
modified	[InstanceEdit:9937589] May, Bruce, 2025-02-03 [InstanceEdit:9944020] May, Bruce, 2025-04-02 [InstanceEdit:9949648] May, Bruce, 2025-05-23
name	TRMT61B methylates adenosine-616 and adenosine-617 of MT-CYB mRNA
output	[EntityWithAccessionedSequence:9937510] m1A616,617-MT-CYB mRNA [mitochondrial matrix] [Homo sapiens] [SimpleEntity:2162252] AdoHcy [mitochondrial matrix] [SimpleEntity:2162252] AdoHcy [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:6785722] Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript [Homo sapiens] [BlackBoxEvent:9986204] POLRMT:TEFM:mitochondrial genome:H,L strand transcript:MTERF1 dissociates [Homo sapiens]
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9937539] R-HSA-9937529.1
summation	[Summation:9937588] TRMT61B methylates the N1 position in adenosine residues of ...
(hasEvent)	[Pathway:9937008] Mitochondrial mRNA modification [Homo sapiens]
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No pathways have been reviewed or authored by TRMT61B methylates adenosine-616 and adenosine-617 of MT-CYB mRNA (9937529)